Intervention : Topical Melatonin(3%) at dosage of 15 mg once daily

Oral Leukoplakia

Topical melatonin at 3% concentration with dosage of 15 mg once daily will be applied on the lesion for 6 weeks followed by a follow up of 3 months

topical melatonin

Topical application of placebo once daily for 6 weeks with a follow up for 3 months

PLACEBO

Post graduate institute of dental sciences

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia: A Randomized Placebo Controlled Study

measurement of the lesion and scored according to RECIST criteria

Grading of dysplasia according to Speight classification (2007).

Percentage of a total number of Ki-67 positive cells to a total number of cells will be primarily deducted.

Postgraduate Institute of Dental Sciences Rohtak

Pediatric Dilated Cardiomyopathy

Water-soluble Ubiquinol

Chung Shan Medical University

Potential Role of Water-soluble Ubiquinol in Complementary Therapy for Pediatric Dilated Cardiomyopathy

Left ventricular ejection fraction (%) will be measured by cardiac echo.

Plasma coenzyme Q10 (micromol/L) will be measured by high performance liquid chromatography.

BNP (pg/mL) will be measured by fluorescence immunoassay.

MDA (micromol/L) will be measured by thiobarbituric acid reacting substance.

red blood cells level of CAT in unit/mg protein.

red blood cells level of GPx in unit/mg protein.

red blood cells level of SOD in unit/mg protein.

hs-CRP (mg/dL) will be measured by Immunoturbidimetry.

IL-6 (pg/dL) will be measured by immunosorbent assay.

Principal Investigator

Kidney Disease

Hypoxyprobe-1 is a biological marker used to detect oxygen levels in tissue;subjects will receive and intravenous solution for 20 minutes containing 500mg/m^2 two-three hours prior to their standard of care biopsy

Hypoxyprobe-1

Wisconsin Institute for Medical Research (WIMR)

University of Wisconsin Hospital and Clinics

Role of Nox2 in CNI-induced Renal Fibrosis

The Role of Nox2 in CNI-Induced Renal Fibrosis

The Nox2 protein will be determined in subjects who are potentially have CNI nephrotoxicity

12 months after a baseline BOLDMRI, subjects will have a second BOLD MRI in order to determine whether there is increased oxygenation

catalase/атрофија

Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia

Potential Role of Water-soluble Ubiquinol in Complementary Therapy for Pediatric Dilated Cardiomyopathy

Role of Nox2 in CNI-induced Renal Fibrosis

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