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cholera/дијареја

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Страна 1 од 41 резултати

Single Dose Azithromycin to Prevent Cholera in Children

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Vibrio cholerae causes 3 million cases of cholera and 100,000 deaths annually. An ongoing epidemic in Yemen has caused 1.7 million cases of cholera, with 58% of cholera-related deaths occurring in children. The World Health Organization (WHO) has targeted the elimination of cholera transmission by

Cholera Anti-Secretory Treatment Trial

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This is a single-center, randomized, double-blind, placebo-controlled trial to evaluate the therapeutic efficacy of oral doses of iOWH032 on diarrhea output and clinical symptoms after a cholera challenge. There will be 24 study participants challenged in the first cohort and an additional 24 study

Zinc Sulfate Acceptability

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Background: Zinc is a metalloprotein. The two important function of zinc are- first, unlike other metals zinc is virtually non-toxic (1). The homeostatic mechanisms that regulate its entrance, allocation, and excretion from cells and tissues are so well-organized that no disorders are known to be

Cholera-Hospital-Based-Intervention-for-7-days

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The findings from the recent randomized controlled trial of The Cholera Hospital Based Intervention for 7 Days (CHoBI7) demonstrated that this intervention was effective in significantly reducing symptomatic cholera infections in intervention households, and had significant sustained impacts on hand

Lactoferrin for Treatment of Iron Deficiency Anemia.

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Anemia is a great public health problem affecting both developing and developed countries. It is considered the most prevalent form of malnutrition in children and adolescents. Supplementation with standard iron therapy is the main treatment of iron deficiency anemia. There are two types of iron

Immunogenicity of Co-administered Oral Polio Vaccine and Oral Cholera Vaccine

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Objectives of the study: Primary : 1. To compare seroconversion for OPV types P1 and P3 when administered alone versus when administered with OCV on day 28 and 56 after vaccination. 2. To compare vibriocidal antibody response (based on a ≥ 4-fold rise) to OCV when administered alone versus when

Tolerability and Acceptability of Fibersol-2 in Children

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To conduct an exploratory study to understand the digestive tolerability of resistant maltodextrin (Fibersol-2) in young healthy and diarrhea children aged 1-3 years for 30 children at home and 30 children at hospital in phase 1. Additionally, propose to conduct a placebo-controlled, randomized,

Immunologic Responses to a Live Attenuated Oral Cholera Vaccine

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Cholera is a life-threatening illness that causes diarrhea. Cholera is caused by eating or drinking the Vibrio cholera bacteria. Each year, there are about 1.3 to 4.0 million cases of cholera worldwide, resulting in 21,000 to 143,000 deaths. The bacteria is spread through water or food that has

Safety of An Oral O1 / O139 Cholera Vaccine (Enteric Capsules)

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Cholera is an acute enteric infectious disease caused by the bacterium Vibrio cholera, leading to watery diarrhea and loss of fluids from the small intestines. The disease can quickly lead to severe dehydration and death without proper and timely management. The World Health Organization (WHO)

Evaluation of a mHealth Platform for Diarrheal Disease Decision-support

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Technology is making possible new approaches to overcome old public health challenges. Cellular networks are now ubiquitous in resource-poor settings and offer new opportunities for high-yield interventions for both chronic and acute diseases. We are specifically interested in developing mHealth

Efficacy of an Oral, Killed Enterotoxigenic Escherichia Coli Vaccine in Prevention of Diarrhea in Egyptian Infants and Young Children

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Pilot Study of Oral Probiotic Bacteria Supplementation to Reduce Chronic Immune Activation in HIV-infected Malian Women

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Excessive immune system stimulation, activation, and associated inflammation play a central role in the pathogenesis of HIV disease. The level of T-cell and monocyte activation predicts the rate of HIV disease progression to AIDS, the slope of CD4+ T-cell loss, and mortality [Liu 1997, Liu 1998,

64N Nutraceutical for the Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings

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Diarrheal disease and pneumonia are two of the top four causes of mortality in children under the age of five . In 2010, 64 percent of deaths in this age group were due to infectious causes. A majority of these deaths occur in developing countries. Although vaccines have been proven to prevent

Evaluation of a Pilot Program to Introduce Cholera Vaccine in Haiti as Part of Global Cholera Control Efforts

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Efficacy of iOWH032 in Dehydrating Cholera

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This is a Phase 2, randomized, double-blind, placebo-controlled study of iOWH032 in adult patients (Part A) and then pediatric patients (Part B) with acute watery diarrhea of less than 24 hours' duration due to cholera. All subjects will be treated with standard of care (IV rehydration fluids, ORS,
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