Birch allergic patient receiving 3 consecutive nasal challenges with birch extract (Allergopharma). Total dose of 1.5ug of Bet v 1 per challenge

Birch allergic patient receiving 3 consecutive nasal challenges with sterile NaCl 0.9%. Total dose of 100ul per nostril per challenge

Allergic Rhinitis

Allergic Inflammation

Nasal spray containing birch extract from Allergopharma

Nasal Provocation with Birch Extract

Nasal spray containing sterile sodium chloride 0.9%

Nasal Provocation with NaCl 0.9%

8H1.02, ENT Lab, Department of Otorhinolaryngology, Vienna General Hospital

Changes in Adaptive Immune Responses and Effector Cell Responses Upon Nasal Allergen Exposure - a Pilot Study

To assess changes of allergen specific IgE levels after challenge with Birch pollen extract

To assess changes in allergen-specific IgE levels in nasal secretions after nasal provocation with birch pollen extract

To assess changes in total IgE levels after nasal provocation with birch pollen extract

To assess changes in allergen-specific and total IgA, IgD, IgG (including subtypes) and IgM levels in sera and nasal secretions after nasal provocation with birch pollen extract by ELISA

To assess changes in TH2 cytokine patterns in sera and nasal secretions after nasal provocation with birch pollen extract. This we be determined by ELISA or Luminex assay which will mean cytokine measurements will have the same units of measure.

To assess presence and changes in IgE production (i.e., by RT-PCR with primers specific for IgE) in nasal mucosa

To assess changes in nasal symptoms using the validated scoring system, Total Nasal Symptom Score (TNSS). On this scale 4 nasal symptoms are assessed namely sneezing, rhinorrhea, nasal itching and nasal blockage on a scale of 0 (no symptoms) 1 (mild symptom burden), 2 (moderate symptom burden) or 3 (severe symptom burden). The scores a totaled and a score out of 12 is produced. Higher values represent greater allergic symptom burden.

To objectively assess the degree of change in nasal blockage by PNIF

To assess the changes in skin reactivity to allergen in a titrated skin prick test to birch pollen extract

Ass.Prof.Dr.med. Josef Toth

Associate Professor, Doctor of Medicine

Medical University of Vienna

In this single-center, randomized, placebo-controlled, double-blind study a total of 36 patients will be recruited into this study on a voluntary basis and will be randomised to receive a nasal challenge with either birch pollen extract or placebo.

corylus avellana/рак

Changes in Adaptive Immune Responses and Effector Cell Responses Upon Nasal Allergen Exposure - a Pilot Study

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