esophageal neoplasms/hypoxia

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Durvalumab as Maintenance Following Chemoradiation for Unresectable Esophageal Squamous Cell Carcinoma

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A) Study Title: Durvalumab (MEDI4736) as maintenance treatment following chemoradiation for locally advanced unresectable esophageal squamous cell carcinoma (DESC) B) Protocol Number: ESR-17-12757 C) Clinical Phase: 2 D) Study Duration: 36 months E) Investigational Product(s) and Reference Therapy:

Strategies to Reduce Postoperative Pulmonary Complications in Robot-assisted Esophagectomy: Intraoperative Monitoring of Oxygen Reserve Index

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Assessment of Graft Perfusion and Oxygenation for Improved Outcome in Esophageal Cancer Surgery

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Background: The incidence of adenocarcinoma of the esophagus is rapidly increasing, resulting in 480 000 newly diagnosed patients annually in the world1. Surgery remains the cornerstone of therapy for curable esophageal cancer (EC) patients. After the esophagectomy, the stomach is most commonly used

Transnasal Endoscopy in Obese Patients Are Candidates for Bariatric Surgery

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1. - Introduction - scientific background, relevance and rationale of the research According to data from 2014 of the World Health Organization (WHO), globally there are more than 1.9 billion adults are overweight and at least 600 million obese. 39% of adults above 18 years were overweight and 13%

PET-CT vs DWI-MRI in Response Evaluation in Esophageal Cancer

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DWI-MRI seems effective in pre-treatment prediction of treatment outcome. Tumor hypoxia mediates chemoradiation resistance, leading to selection of aggressive tumor cell clones with the capacity to evade tumor microenvironment by increased anaerobic glycolysis and angiogenesis. Apparent diffusion

Tumor Hypoxia With HX4 PET in Several Diseases

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Rationale: Non-invasive imaging of hypoxia with the aid of PET-scans could help to select the patients having a hypoxic tumor, who could be treated with specific anti-hypoxic treatments. The added value of additional anti-hypoxic treatments depends on the presence of hypoxia and adequate patient

Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer.

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Rationale: Neoadjuvant chemoradiotherapy followed by surgery remains the standard of care for esophageal cancer patients. Both limited local response as well as distant metastases are a common cause of treatment failure. Combining TH-302 with chemo-radiotherapy may improve outcome by: - Direct

Innovative MRI Techniques to Improve Treatment Stratification of Patients With Esophageal Cancer

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The outcome of esophageal cancer is poor, with an overall 5-year survival rate of 10% worldwide. In resectable esophageal cancer, outcome can be improved by multimodality treatment. The current standard treatment of resectable esophageal cancer consists of neoadjuvant chemoradiation followed by

Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches

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Background: Esophageal cancer is a common malignant tumor in China and worldwide with poor prognosis. Although the surgical resection combined with adjuvant therapy constitutes the mainstay of the treatment the esophagectomy-associated complications are still life-threatening. Postoperative

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