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Cancer diagnosis by measuring polyisoprenylated methylated protein methyl esterase activity

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BACKGROUND OF THE INVENTION It has been discovered that the activity of a particular enzyme, polyisoprenylated methylated protein methyl esterase (PMPMEase which is also known as human carboxylesterase 1 or hCE1), is elevated in certain cancers, particularly in breast cancer. The present invention

Cancer diagnosis by measuring polyisoprenylated methylated protein methyl esterase activity

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BACKGROUND OF THE INVENTION It has been discovered that the activity of a particular enzyme, polyisoprenylated methylated protein methyl esterase (PMPMEase which is also known as human carboxylesterase 1 or hCE1), is elevated in certain cancers, such as in breast cancer. The present invention is

Compounds and methods for the selective treatment of cancer and bacterial infections

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FIELD OF THE INVENTION The present invention relates to a new class of glucuronides, esters, and glycosides whose aglycone activity is more highly toxic than normally found for such compounds, as well as to methods of preparation of such glucuronides, esters, and glycosides. The present invention

Tumor markers for ovarian cancer diagnosis

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tumor marker for diagnosis of cancer, especially for diagnosis of ovarian cancer, which can be applied in early diagnosis of ovarian cancer. 2. The Prior Arts Human ovarian cancer is one of the common

Method and composition for treating prostate cancer

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FIELD OF THE INVENTION The present invention is directed to a method for treating prostate cancer by administering collagenase alone or in combination with a glycosidase, a protease, a nuclease, a lipase, an esterase, a streptokinase, or a combination thereof. A typical embodiment includes

Method and composition for treating prostate cancer

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Quinolones and their therapeutic use

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FIELD OF THE INVENTION The present invention relates to the therapeutic use of quinolone derivatives, and to certain novel such compounds. BACKGROUND OF THE INVENTION Quinolone compounds are known primarily as antibacterial agents (see JP-A-05025162; U.S. Pat. No. 5,037,834; EP-A-0420069;

Quinolones and their therapeutic use

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Aldophosphamides

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BACKGROUND OF THE INVENTION The present invention relates to cyclophosphamide analogs particularly useful for the suppression of tumor cells. Since the demonstration in 1942 that nitrogen mustard was effective at inducing remission in patients with lymphoma (A. Gilman (1063) Amer. J. Surg. 105:574),

Amide, aryl sulfonamide, aryl urea, and .alpha.,.beta.-diketone derived carboxylesterase inhibitors, and their methods of use

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FIELD OF THE INVENTION This invention is directed to the use of amide, aryl sulphonamide, aryl urea, and .alpha.,.beta.-diketone compounds as carboxylesterase inhibitors, and particularly to the use of these compounds as selective human intestinal carboxylesterase inhibitors. The compounds are also

Thrombin derived polypeptides: compositions and methods for use

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is directed to chemical compounds and methods useful in the regulation of thrombin receptor mediated cell stimulation. More specifically, the invention is directed to prothrombin-derived peptides and methods which employ

Thrombin derived polypeptides; compositions and methods for use

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Thrombin derived polypeptides; compositions and methods for use

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Antitumor aldophosphamide glycoside and dideoxyuridine derivatives

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BACKGROUND OF THE INVENTION The present invention relates to cyclophosphamide analogs particularly useful for the suppression of tumor cells. Since the demonstration in 1942 that nitrogen mustard was effective at inducing remissions in patients with lymphoma (A. Gilman Amer. J. Surg. 105:574),

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