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Страна 1 од 17 резултати
Use of fructose-based compounds for the diagnosis of cancer
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FIELD OF INVENTION
This invention relates to compositions, methods utilizing fructose and other monosaccharides for the diagnosis of cancer.
BACKGROUND
All publications herein are incorporated by reference to the same extent as if each individual publication or patent application was specifically
Fructose 1, 6-biphosphatases as new targets for diagnosing and treating breast cancer brain metastasis
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GOVERNMENTAL SPONSORSHIP
Not Applicable.
FIELD OF THE INVENTION
The present invention is directed to compositions and methods for diagnosing and treating cancer cells by targeting fructose-1,6-biphosphatase(EC:3.1.311) enzymes (FBPs, type 1 and type 2) and/or their respective pathways. More
Fructose analogs and their combinations as anti-cancer agents
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TECHNICAL FIELD
The present invention relates to the field of biomedicine, and relates specifically to the use of fructose analogs and the combination of fructose analogs and glucose analogs in the treatment of cancer and organ fibrosis.
BACKGROUND
It is well known that the occurrence and
Fluorinated fructose derivatives for PET imaging
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FIELD OF THE INVENTION
This invention relates to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies.
BACKGROUND OF THE
PFKB3 inhibitor for the treatment of a proliferative cancer
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TECHNICAL FIELD
The presently disclosed subject matter relates to methods and compounds for reducing glycolytic flux. More particularly, the presently disclosed subject matter relates to aza chalcones and analogs thereof that inhibit 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3),
Inhibitors of PFKFB3 for cancer therapy
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FIELD OF THE INVENTION
This invention relates to inhibitors of mammalian energy metabolism, more particularly it relates to compounds used to inhibit one of the isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) involved in glycolysis, and more particularly it relates to
Methods and compositions for diagnosing and treating gastric cancer
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FIELD OF THE INVENTION
The present invention relates to the field of gastric cancer. More specifically, the present invention provides methods and compositions for diagnosing and treating gastric cancer.
BACKGROUND OF THE INVENTION
Gastric cancer (GC), a disease with a very poor prognosis, is the
Synthetic glycoamines and methods for their use that affect cell adhesion, inhibit cancer cell metastasis, and induce apoptosis
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FIELD OF THE INVENTION
The present invention relates to pharmaceuticals that affect cell adhesion, inhibit cancer cell metastasis, and induce apoptosis both in vitro and in vivo.
Background of the Invention
Cell adhesion is one important property that differentiates multi-cellular organisms from
Family of PFKFB3 inhibitors with anti-neoplastic activities
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TECHNICAL FIELD
The presently disclosed subject matter relates to methods and compounds for reducing glycolytic flux. More particularly, the presently disclosed subject matter relates to aza chalcones and analogs thereof that inhibit 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3),
Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics
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The presently-disclosed subject matter relates to small-molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and methods of using the same. In particular, the presently-disclosed subject matter relates to substituted benzindoles as PFKFB3 inhibitors and methods of
PFKFB3 inhibit and methods of use as an anti-cancer therapeutic
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TECHNICAL FIELD
The presently disclosed subject matter relates to a novel anti-cancer agent, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-e- n-1-one, as an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and methods of using the same to treat cancer
PFKFB3 inhibitor and methods of use as an anti-cancer therapeutic
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TECHNICAL FIELD
The presently disclosed subject matter relates to a novel anti-cancer agent, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-e- n-1-one, as an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and methods of using the same to treat cancer
PFKFB4 inhibitors and methods of using the same
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FIELD OF THE INVENTION
The presently-disclosed subject matter relates to 6-phosphofructo-2-kinase/fructose-2,6-bisphophatase 4 (PFKFB4) inhibitors and methods of using the same. In particular, the presently-disclosed subject matter relates to PFKFB4 inhibitors, including small interfering RNA
Physiologically active peptides and a process for preparation thereof
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The following examples illustrate the present invention, but it is to be understood that they are given for the purpose of illustration and not limitation.
EXAMPLE 1
A medium (100 l) containing 6.0% soluble starch, 4.0% cotton seed meal, 0.2% (NH.sub.4).sub.2 SO.sub.4, 0.1% yeast extract, 0.2%
Isolate of Antrodia camphorata process for producing a culture of the same and product obtained thereby
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FIELD OF THE INVENTION
The present invention relates a process for culturing isolates of Antrodia camphorata to provide a product useful in medical and nourishment fields. The present invention also relates to a novel isolate of Antrodia camphorata, the culture of which exhibits pharmacological
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