glyceollin/запаљење

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Anti-inflammatory effects of glyceollins derived from soybean by elicitation with Aspergillus sojae.

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OBJECTIVE Given the preventive effect of soy intake against several chronic diseases, this study was conducted to investigate the inhibitory activity against inflammatory response of phytoalexins glyceollins derived from soybean isoflavones by treatment with a biotic elicitor. METHODS Using RAW264.7

Anti-septic effects of glyceollins in HMGB1-induced inflammatory responses in vitro and in vivo.

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The ubiquitous nuclear protein High mobility group box 1 (HMGB1) is released by activated macrophages and human umbilical vein endothelial cells (HUVECs), and functions as a late mediator of experimental sepsis. Glyceollins (GCLs) are active compounds from Aspergillus sojae which have been reported

Soyabean glyceollins: biological effects and relevance to human health.

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Glyceollins, one family of phytoalexins, are de novo synthesised from daidzein in the soyabean upon exposure to some types of fungus. The efficiency of glyceollin production appears to be influenced by soyabean variety, fungal species, and the degree of physical damage to the soyabean. The compounds

Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration.

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Platelet-derived growth factor (PDGF)-BB can induce abnormal proliferation and migration of vascular smooth muscle cells (VSMC) that are involved in the development of CVD. In our preliminary study, phytoalexin glyceollins (glyceollins I, II and III) isolated from soyabean seeds cultured with

Soybean glyceollins mitigate inducible nitric oxide synthase and cyclooxygenase-2 expression levels via suppression of the NF-κB signaling pathway in RAW 264.7 cells.

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Glyceollins, produced to induce disease resistance responses against specific species, such as an incompatible pathogen Phytophthora sojae in soybeans, have the potential to exhibit anti-inflammatory activity in RAW 264.7 cells. To investigate the anti-inflammatory effects of elicited glyceollins

Protective Effect of Glyceollins in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.

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Glyceollins, which are derived from daidzein in soybean in response to various stimuli or stresses, have been reported to activate antioxidant/detoxifying enzymes in a nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-dependent manner, in addition to exerting anti-inflammatory effects in murine

Hormesis of glyceollin I, an induced phytoalexin from soybean, on budding yeast chronological lifespan extension.

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Glyceollin I, an induced phytoalexin isolated from soybean, has been reported to have various bioactivities, including anti-bacterial, anti-nematode, anti-fungal, anti-estrogenic and anti-cancer, anti-oxidant, anti-inflammatory, insulin sensitivity enhancing, and attenuation of vascular

Modification of miRNA Expression through plant extracts and compounds against breast cancer: Mechanism and translational significance.

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Cancer is hyper-proliferative, multi-factorial and multi-step, heterogeneous group of molecular disorders. It is the second most reported disease after heart diseases. Breast carcinoma is the foremost death causing disease in female population worldwide. Cancer can be controlled by

A novel gastrointestinal microbiome modulator from soy pods reduces absorption of dietary fat in mice.

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OBJECTIVE Simplification of diets, low in variety but high in energy, contributes to the loss in diversity observed in the obese gastrointestinal (GI) microbiome. A novel GI microbiome modulator (GIMM) as a dietary intervention was developed. METHODS Mice were fed either an obesogenic diet (ObD) or

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