leukemia/phosphatase

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Reagents for the detection of protein phosphorylation in leukemia signaling pathways

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RELATED APPLICATIONS This application claims the benefit of, and priority to, PCT serial number PCT/US06/034050, filed Aug. 31, 2006, presently pending, the disclosure of which is incorporated herein, in its entirety, by reference. FIELD OF THE INVENTION The invention relates generally to antibodies

Use of phosphotyrosine phosphatase inhibitors for controlling cellular proliferation

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BACKGROUND OF THE INVENTION This invention is directed to the use of phosphotyrosine phosphatase inhibitors for controlling cellular proliferation, particularly proliferation of B lymphocytes. Tyrosine phosphorylation is known to play an essential role in the control of lymphocyte function. This

Use of phosphotyrosine phosphatase inhibitors for controlling cellular proliferation

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18232, a novel dual specificity phosphatase and uses therefor

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BACKGROUND OF THE INVENTION The intracellular phosphorylation of proteins is critical for a plethora of regulatory and signalling mechanisms in eukaryotic cells. Phosphorylation events can govern a wide range of cellular processes, including cell proliferation, differentiation, transcription, and

Phosphotyrosine phosphatase inhibitors or phosphotyrosine kinase activators for controlling cellular proliferation

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BACKGROUND OF THE INVENTION This invention is directed to the use of phosphotyrosine phosphatase inhibitors and tyrosine kinase activators for controlling cellular proliferation, particularly proliferation of lymphocytes. Tyrosine phosphorylation is known to play an essential role in the control of

Use of phosphotyrosine phosphatase inhibitors or phosphotyrosine kinase activators for controlling cellular proliferation

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BACKGROUND OF THE INVENTION This invention is directed to the use of phosphotyrosine phosphatase inhibitors and phosphotyrosine kinase activators for controlling cellular proliferation, particularly proliferation of lymphocytes. Tyrosine phosphorylation is known to play an essential role in the

Method and compositions for treatment of BCR-ABL associated leukemias and other cell proliferative disorders

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TABLE OF CONTENTS 1. Introduction 2. Background 2.1. Protein Phosphorylation and Signal Transduction 2.2. Protein Tyrosine Kinases 2.3. G-Proteins and Signal Transduction 2.4. BCR-ABL in the Development of Leukemias 3. Summary of the Invention 3.1. Abbreviations 4. Description of the Figures 5.

Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases

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BACKGROUND OF THE INVENTION Intercellular protein tyrosine phosphorylation is regulated by extracellular stimuli, such as cytokines, to control cell growth, differentiation and functional activities. This signaling mechanism depends on the interplay of protein tyrosine kinases, which initiate

Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases

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Method of diagnosing cancer and reagents therefor

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FIELD OF THE INVENTION The present invention relates to the epigenetic state of a region of chromatin within the region of Chromosome 2 from about map position 2q14.1 to about 2q14.3 and its use to diagnose and/or monitor and/or prognose cancer BACKGROUND OF THE INVENTION 1. General This

Use of phosphotyrosine phospatase inhibitors for controlling cellular proliferation

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Treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals using carprofen and derivatives

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The present invention relates to the use of carprofen in mammals as a means of treating and preventing cartilage and subchondral bone injury and loss in the inflamed joints of such mammals. Such damage to the cartilage and subchondral bone is a natural sequelae of the process of osteoarthritis and

Method of increasing efficacy of tumor cell killing using combinations of anti-neoplastic agents

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to the field of treatment of neoplastic diseases and uncontrolled cell growth. More specifically, it relates to compositions and methods for treating tumors or cancers with combinations of a substance that activates

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