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12 резултати

Tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives as cannabinoid CB1 receptor agonists

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The present invention relates to tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives, to pharmaceutical compositions comprising the same and to the use of these tricyclic 1-[(indol-3-yl)carbonyl]piperazine derivatives in therapy, especially in the treatment of pain. Pain treatment is often

Cannabinoid receptor modulators

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CROSS-REFERENCE TO RELATED APPLICATIONS This application is a National Stage Application under 35 U.S.C. .sctn.371 of International Application No. PCT/US2010/002360, filed Aug. 27, 2010, which claims priority under 35 U.S.C. .sctn.119(e) to U.S. Provisional Application Nos. 61/275,506, filed Aug.

Cannabinoid receptor modulators

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FIELD OF THE INVENTION The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB.sub.2 receptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions

4,5 dihydro-(1H)-pyrazole derivatives as cannabinoid CB.sub.1 receptor modulators

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The present disclosure relates to the fields of pharmaceutical and organic chemistry, and provides 4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB.sub.1 receptor modulators, intermediates for synthesizing these compounds, formulations comprising these compounds, methods for

Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators

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BACKGROUND OF THE INVENTION Marijuana (Cannabis sativa L.) and its derivatives have been used for centuries for medicinal and recreational purposes. A major active ingredient in marijuana and hashish has been determined to be .DELTA..sup.9-tetrahydrocannabinol (.DELTA..sup.9-THC). Detailed research

Aralkyl amines as cannabinoid receptor modulators

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BACKGROUND OF THE INVENTION Marijuana (Cannabis sativa L.) and its derivatives have been used for centuries for medicinal and recreational purposes. A major active ingredient in marijuana and hashish has been determined to be .DELTA.9-tetrahydrocannabinol (.DELTA.9-THC). Detailed research has

Substituted imidazoles as cannabinoid receptor modulators

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SUMMARY OF THE INVENTION The present invention is concerned with substituted imidazole of the general Formula I: ##STR00001## and pharmaceutically acceptable salts thereof which are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention

Substituted imidazoles as cannabinoid receptor modulators

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SUMMARY OF THE INVENTION The present invention is concerned with substituted imidazole of the general Formula I: ##STR00001## and pharmaceutically acceptable salts thereof which are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention

Diphenyl cyclopentyl amides as cannabinoid-1 receptor inverse agonists

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BACKGROUND OF THE INVENTION Marijuana (Cannabis sativa L.) and its derivatives have been used for centuries for medicinal and recreational purposes. A major active ingredient in marijuana and hashish has been determined to be .DELTA..sup.9-tetrahydrocannabinol (.DELTA..sup.9-THC). Detailed research

Crystalline forms and processes for the preparation of cannabinoid receptor modulators

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FIELD OF THE INVENTION The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclop- ropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that

Crystalline forms and processes for the preparation of cannabinoid receptor modulators

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FIELD OF THE INVENTION The present invention relates to crystalline forms of (1aS,5aS)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1H-2,3-diaza-cyclop- ropa[a]pentalene-4-carboxylic acid ((S)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (Compound 1) and pharmaceutical compositions thereof that

Synthetic endogenous cannabinoids analogues and uses thereof

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STATEMENT OF THE INVENTION The present invention relates to compounds of the general formula (I), to a process for their preparation, to pharmaceutical compositions containing at least one compound of the invention and to the different uses of said compounds. BACKGROUND OF THE INVENTION Anandamide
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