Myocardial infarction / otok

Prodrug salts

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TECHNICAL FIELD Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their

Prodrug salts

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TECHNICAL FIELD Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their

Indolylmaleimide derivatives

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The present invention relates to indolylmaleimide derivatives, process for their production and pharmaceutical compositions containing them. More particularly the present invention provides a compound of formula I ##STR00002## wherein R.sub.a is H; CH.sub.3; CH.sub.2--CH.sub.3; or isopropyl, R.sub.b

Indolylmaleimide derivatives

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The present invention relates to indolylmaleimide derivatives, process for their production and pharmaceutical compositions containing them. More particularly the present invention provides a compound of formula I ##STR00002## wherein R.sub.a is H; CH.sub.3; CH.sub.2--CH.sub.3; or isopropyl, R.sub.b

Chimeric and humanized anti-histone antibodies

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size. FIELD OF THE

Chimeric and humanized anti-histone antibodies

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FIELD OF THE INVENTION The invention relates to compositions and methods of use of anti-histone antibodies or antigen-binding fragments thereof. In particular embodiments, the antibodies bind to human histones H2B, H3 or H4. The anti-histone antibodies are of use for diagnosis and/or therapy of a

Nucleic acids encoding chimeric and humanized anti-histone antibodies

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size. FIELD OF THE

Methods for treating thrombosis using chimeric and humanized anti-histone antibodies

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size. FIELD OF THE

Methods for treating sepsis using chimeric and humanized anti-histone antibodies

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size. FIELD OF THE

Methods for treating ischemic stroke using chimeric and humanized anti-histone antibodies

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1_SL.txt and is 71,342 bytes in size. FIELD OF THE

Methods of treating rapidly progressive glomerulonephritis using chimeric and humanized anti-histone H4 antibodies

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2014, is named IMM342US1 SL.txt and is 71,342 bytes in size. FIELD OF THE

Methods of screening for compounds which bind G protein-coupled receptors

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CROSS-REFERENCE TO RELATED APPLICATIONS This application is the 35 U.S.C. .sctn.371 national stage of PCT application PCT/JP2005/007354, filed Apr. 11, 2005, which claims priority to Japanese patent application No. 116725/2004, filed Apr. 12, 2004. The contents of these applications are incorporated

Therapeutic application of Kazal-type serine protease inhibitors

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This is a national stage entry of PCT/EP2008/001009, filed Feb. 11, 2008, which claims priority to EP 07002903.8, filed Feb. 12, 2007, all of which are incorporated herein by reference. The subject of the present invention is, in the most general aspect, the therapeutic application of the Kazal-type

Pyrazolopyridine compounds which have useful pharmaceutical utility

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The present invention relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof. More particularly, it relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof, which are adenosine antagonists and posses various pharmaceutical actions

Kinase inhibitors and methods of use thereof

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FIELD OF THE INVENTION The present invention relates generally to kinase inhibitors and lipid kinase inhibitors and more specifically to phosphoinositide kinase inhibitors and methods of use for such inhibitors in attenuating the effects of compromised vasculostasis, and further in treating

myocardial infarction/otok

Prodrug salts

Prodrug salts

Indolylmaleimide derivatives

Indolylmaleimide derivatives

Chimeric and humanized anti-histone antibodies

Chimeric and humanized anti-histone antibodies

Nucleic acids encoding chimeric and humanized anti-histone antibodies

Methods for treating thrombosis using chimeric and humanized anti-histone antibodies

Methods for treating sepsis using chimeric and humanized anti-histone antibodies

Methods for treating ischemic stroke using chimeric and humanized anti-histone antibodies

Methods of treating rapidly progressive glomerulonephritis using chimeric and humanized anti-histone H4 antibodies

Methods of screening for compounds which bind G protein-coupled receptors

Therapeutic application of Kazal-type serine protease inhibitors

Pyrazolopyridine compounds which have useful pharmaceutical utility

Kinase inhibitors and methods of use thereof

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