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Страна 1 од 17 резултати
Contribution of TGFβ1 codon 10 polymorphism to high myopia in an ethnic Kashmiri population from India.
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This study looks at novel variants of the TGFβ1 gene and their potential association with high myopia in an ethnic population from Kashmir, India. Allele frequencies of 247 Kashmiri subjects (from India) with high myopia and 176 ethnically matched healthy controls were tested for Hardy-Weinberg
Inhibition of matrix metalloproteinase activity in the chick sclera and its effect on myopia development.
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OBJECTIVE
To investigate the contribution of matrix degradation in the two-layer avian sclera to the development of myopia.
METHODS
Tissue inhibitor of metalloproteinase-2 (TIMP-2) was used to inhibit chick scleral collagen degradation with (3)H-proline, a marker for this effect. Ex vivo scleral
Effects of scleral collagen crosslinking with different carbohydrate on chemical bond and ultrastructure of rabbit sclera: Future treatment for myopia progression.
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TGIF1 is a potential candidate gene for high myopia in ethnic Kashmiri population.
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OBJECTIVE
High myopia is a complex disorder that imposes serious consequences on ocular health. Linkage analysis has identified several genetic loci with a series of potential candidate genes that reveal an ambiguous pattern of association with high myopia due to population heterogeneity. We have
Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations.
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Myopia, the leading cause of visual impairment worldwide, results from an increase in the axial length of the eyeball. Mutations in LEPREL1, the gene encoding prolyl 3-hydroxylase-2 (P3H2), have recently been identified in individuals with recessively inherited nonsyndromic severe myopia. P3H2 is a
Prolidase deficiency associated with pathologic myopia.
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Deficiency of prolidase, a key enzyme in proline metabolism, is extremely rare and is usually associated with skin lesions, recurrent infections, characteristic facies, mental retardation, and splenomegaly. These clinical features are largely due to inhibition of normal recycling of proline, which
Homozygous loss-of-function mutation of the LEPREL1 gene causes severe non-syndromic high myopia with early-onset cataract.
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High myopia is a severe visual impairment which can increase the risk of retinal degeneration, subretinal hemorrhage, choroidal neovascularization, cataract and retinal detachment. We recruited an autosomal-recessive high myopia family, with affected subjects who also present early-onset cataract,
Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia.
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The development of high myopia is associated with reduced scleral collagen accumulation, scleral thinning, and loss of scleral tissue, in both humans and animal models. Reduced collagen fibril diameter is also observed in the sclera of eyes with high myopia. The present study investigated aspects of
Biochemical and ultrastructural changes in rabbit sclera after treatment with 7-methylxanthine, theobromine, acetazolamide, or L-ornithine.
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OBJECTIVE
To examine a possible effect of 7-methylxanthine, theobromine, acetazolamide, or L-ornithine on the ultrastructure and biochemical composition of rabbit sclera.
METHODS
Groups of pigmented rabbits, six in each group, were dosed during 10 weeks with one of the substances under
[Keratocyte activity in wound healing process following epikeratophakia in rabbits].
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Epikeratophakia is a refractive surgery for the correction of aphakia, high myopia and keratoconus. Although many clinical studies of epikeratophakia have been performed, its wound healing process is not well understood. In the present study, we investigated keratocyte activities, particularly cell
Biochemical changes in rabbit sclera following destruction of pigment epithelium.
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The long-term effect of destruction of the pigment epithelium by sodium iodate on the biochemistry of rabbit sclera was studied in one group with intravenous injection of sodium iodate, and in a second group with injection of sodium iodate into the right eye. Intravenous treatment produced a
Keratocyte activity in wound healing after epikeratophakia in rabbits.
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Epikeratophakia is a refractive surgical procedure for the correction of aphakia, high myopia, or keratoconus. To solve clinical problems associated with epikeratophakia, a basic knowledge of its postoperative healing process is needed. The authors investigated keratocyte activities, particularly
Cortical Representation of a Myopic Peripapillary Crescent.
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To determine how formation of an acquired myopic crescent adjacent to the optic disc affects metabolic activity in the primary visual cortex.
Laboratory animal study.
Three macaque monkeys.
The blind spot region in the primary visual cortex was labeled by cytochrome oxidase (CO) histochemistry
Visual deprivation upregulates extracellular matrix synthesis by chick scleral chondrocytes.
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OBJECTIVE
To characterize the cellular events responsible for the exaggerated ocular growth associated with experimental myopia in chicks, the accumulation and synthesis of proteoglycans and collagen were measured in the posterior sclera of control and form vision-deprived chick
Identification of genes expressed in a human scleral cDNA library.
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OBJECTIVE
Clones established from a human scleral cDNA library were systematically sequenced. Public database sequence comparisons were performed to generate a profile of genes expressed in the human sclera and identify candidate genes for inherited diseases with scleral involvement.
METHODS
A
Најкомплетнија база лековитог биља подржана науком
- Ради на 55 језика
- Биљни лекови потпомогнути науком
- Препознавање биљака по слици
- Интерактивна ГПС мапа - означите биље на локацији (ускоро)
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