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reticulocytosis/рак
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Страна 1 од 31 резултати
Erythropoietin increases hemoglobin during radiation therapy for cervical cancer.
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OBJECTIVE
Anemia during radiation therapy independently predicts poor outcome in patients with cervical cancer. Despite a randomized trial demonstrating red cell transfusions improve local control and survival, many patients are not transfused due to toxicity concerns. This study evaluates the
Reticulocytosis in non-anaemic cats and dogs.
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OBJECTIVE
To evaluate the proportion of blood samples diagnosed with reticulocytosis without anaemia in cats and dogs and report the aetiology and mortality rate of affected animals.
METHODS
Retrospective multicentre study including haematological examination of 3956 cats and 11,087 dogs admitted to
Characterization of murine hepatoma BW7756. III. Hematological profile of a tumor-associated anemia.
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A severe anemia develops in recipient C57L/J mice after syngeneic transplantation of the BW7756 murine hepatoma. The tumor undergoes an exponential growth spurt in the 14-21 days post-implantation, accompanied by a parallel increase in serum alpha-fetoprotein levels and a significant decrease of
Suppressive effects of an extramedullary tumor on bone marrow erythropoiesis and stroma.
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Mice, bearing a solid extramedullary Ehrlich ascites tumor developed anemia, reticulocytosis, and leukocytosis after 3 weeks of tumor growth. Erythopoiesis in the marrow, as measured by erythroblast counts and radioiron uptake of the humerus and femur, was suppressed to less than 30% of normal.
The hematologic effects of chronic administration of the monokines tumor necrosis factor, interleukin-1, and granulocyte-colony stimulating factor on bone marrow and circulation.
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Monokines may contribute to the regulation of hematopoiesis and circulating numbers of leukocytes during chronic inflammation. The hematologic effects of daily intravenous injection of the recombinant monokines tumor necrosis factor (TNF), interleukin-1 (IL-1), and granulocyte-colony stimulating
Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival.
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The transcription factor p53 suppresses tumor growth by inducing nucleated cell apoptosis and cycle arrest. Because of its influence on primitive erythroid cell differentiation and survival, p53 is an important determinant of erythropoiesis. However, the impact of p53 on the fate of erythrocytes,
Sensitivity to radiation and cycle-active drugs as a function of stem cell compartment repletion.
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We have studied the sensitivity of normal mouse hemopoietic tissue to radiation and cycle-active drugs in relation to stem cell compartment repletion. Recovery of erythropoiesis in endogenous spleen colonies, blood reticulocytes, and 30-day survivals were determined in mice after an initial large
Human erythropoietin gene delivery using an arginine-grafted bioreducible polymer system.
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Erythropoiesis-stimulating agents are widely used to treat anemia for chronic kidney disease (CKD) and cancer, however, several clinical limitations impede their effectiveness. Nonviral gene therapy systems are a novel solution to these problems as they provide stable and low immunogenic protein
Diagnosis and treatment of autoimmune haemolytic anaemias in adults: a clinical review.
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Autoimmune haemolytic anaemia (AIHA) is an immune disorder caused by antibodies directed against unmodified autologous red cells. The disorder may be a primary (idiopathic) or a secondary disease. The diagnosis is based on the presence of anaemia, signs of haemolysis with reticulocytosis, low
Recombinant human erythropoietin for the treatment of the anaemia associated with autologous bone marrow transplantation.
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Patients with solid tumours undergoing high-dose chemotherapy with autologous bone marrow transplantation use an average of 10 units of packed red blood cells (PRBC) while awaiting haemopoietic reconstitution. They are also known to have inappropriately low endogenous erythropoietin levels for their
Erythropoietin-induced polycythemia in athymic mice following transplantation of a human renal carcinoma cell line.
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An established cloned human renal carcinoma line RC-1, which has been continuously maintained in culture for several years and which produces erythropoietin, was injected s.c. into BALB/c athymic mice and produced tumors. Tumorigenicity was directly correlated with the number of RC-1 cells
Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF.
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Certain proteins are known to play an important part in the proliferation, differentiation and functional activation of haematopoietic progenitor cells in vitro. These proteins include erythropoietin and various colony-stimulating factors (CSFs), one of which is granulocyte-macrophage
Benign transient blueberry muffin baby.
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In this case-report a case of severe fetal anemia of unknown origin is presented. Diagnosis of fetal anemia was made at 24 weeks of gestational age, when fetal ascites was identified. Doppler sonography of medium cerebral artery showed a high systolic speed velocity (ACM-PSV), of 65 cm/s (>1.55
Malignant pheochromocytoma accompanied by microangiopathic hemolytic anemia: a case report.
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A 63-year-old woman was in hospital for persistent backache. Four months prior to admission she had been pointed out as having hypertension for the first time. On admission, she had anemia (hemoglobin 7.0 g/dl) with reticulocytosis, and a blood smear showed fragmented erythrocytes. A bone marrow
Enhanced suicidal erythrocyte death in mice carrying a loss-of-function mutation of the adenomatous polyposis coli gene.
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Loss-of-function mutations in human adenomatous polyposis coli (APC) lead to multiple colonic adenomatous polyps eventually resulting in colonic carcinoma. Similarly, heterozygous mice carrying defective APC (apc(Min/+)) suffer from intestinal tumours. The animals further suffer from anaemia, which
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