Multiple Sclerosis

Motor assessment includes:
posturographic examination in Single-task (ST) and Double-task (DT)
an analysis of ST and DT walking;
Timed Up and Go (TUG) performances in real (rTUG) and imagined (iTUG) versions;

Dual TAsk

Effects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients

Ffects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients With Low Level of Disability

The presence of postural instability is determined by a value of oscillation rate greater than 2 standard deviations from the mean of the healthy population used in this study

University Hospital, Limoges

HIV/AIDS

Vitamin D Deficiency

Smoker Lung

Study subjects will receive 2 tablets of vitamin D3 for a total of 450,000 IU by mouth.

Vitamin D3 450,000 IU orally

Atlanta VA Medical center

Grady Health System (non-CRN), Grady Health System (CRN), Ponce Center

Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIV

Effect of High-Dose Vitamin D3 on Alveolar Macrophage Function, LL-37, and Oxidative Stress in Smokers and Non-Smokers With and Without HIV

A phagocytic index will be determined by challenging AM isolated from bronchoalveolar lavage (BAL) to Staph. Aureus in vitro.

Difference in phagocytosis percent positive between HIV+ smokers compared to HIV- non-smokers will be calculated.

Difference in total and free 25(OH) D between HIV+ smokers compared to HIV- non-smokers will be measure by ELISA (enzyme-linked immunosorbent assay) levels.

Difference in an antimicrobial and immunostimulating/-modulating peptide LL-37 between HIV+ smokers compared to HIV- non-smokers will be calculated.

Difference in tumor necrosis factor alpha (TNF-α) - cytokine involved in systemic inflammation - between HIV+ smokers compared to HIV- non-smokers will be calculated .

Difference in mRNA expression of antimicrobial peptide LL-37 between HIV+ smokers compared to HIV- non-smokers will be calculated.

Difference in alveolar oxidative stress between HIV+ smokers compared to HIV- non-smokers will be measured using AM isolated from bronchoalveolar lavage (BAL) .

Difference in total and free vitamin D (25(OH) D) will be measure by ELISA (enzyme-linked immunosorbent assay)

Difference in peptide LL-37 levels will be calculated.

Difference in tumor necrosis factor alpha (TNF-α) will be calculated.

Difference in mRNA expression of LL-37 will be calculated.

Difference in alveolar oxidative stress will be measured using AM isolated from bronchoalveolar lavage (BAL) .

Jenny Elizabeth Han

Assistant Professor

Emory University

A total of 44 subjects (11 per group, smokers and non-smokers, HIV+, HIV-) will be enrolled.

vitamin d deficiency/никотин

Effects of A Dual-Task Intervention in Postural Control in Multiple Sclerosis Patients

Effect of High-Dose Vitamin D3 in Smokers and Non-Smokers With and Without HIV

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