No treatment will be done to these hypopigmented lesions

Acquired Hypomelanosis

One session of microneedling will be performed by using dermaroller 1.5 mm. The microneedling done from the edge of the normal skin towards the center of the hypopigmented lesion in all the directions (horizontal, vertical. diagonal).

Microneedling

Cairo University

Microneedling for Acquired Hypomelanosis

Microneedling for Acquired Hypomelanosis : A Randomized Controlled Trial

drawing the lesion's surface area through transparent stencil paper

The repigmentation assessed by percentage value range from 0- 100% where the 100 % means full repigmentation, the value is a result of an equation where the estimated percentage of marginal repigmentation add to ( remaining area (%) plus estimated percent of perifollicular pigmentation in the remaining area(%) divided by 100)

3-point scale (not satisfied, moderately satisfied, extremely satisfied).

the patient evaluation to lesion by percentage value for repigmentation ranged from 0- 100% which represent full repigmentation.

One unblinded and 2 blinded investigators assessed the global improvement through photographs of the lesions before and after 3 months of therapy. The lesions were photographed on a black background using a single reflex camera with standardized settings (ambient light, same position, and distance from the patient).

Safety as defined by occurrence of pain, bleeding, local infection, skin flaking, and scarring during, shortly after the procedure (2weeks), and at the end of the study.

Julbahar Ibrahim

Dermatology resident,Principal investigator-Cairo university.

The area to be treated will be specified and split into two halves then randomized using sealed envelope into one of both arms: treatment or no treatment.
One session of microneedling using derma roller 1.5 mm will be done.

Subjects in this group will receive at least two Syneron-Candela CO2RE laser treatments set at either the Mid mode or the Deep mode of the laser at visits three months apart. Thereafter, individuals in this group will be offered a third optional treatment at one of these settings.

Subjects in this group will receive at least two Syneron-Candela CO2RE laser treatments set at the Light mode of the laser at visits three months apart. Individuals in this group will be offered two optional high energy treatments subsequent to receiving the two light energy treatments.

Cicatrix

Carbon Dioxide Laser

This fractionated ablative laser will administer energy at either a high intensity setting or a low intensity setting to subjects randomized into a particular treatment group. It will be operated by the principle investigator, who has extensive experience with laser therapy.

Syneron-Candela CO2RE Laser

Saint Louis University Department of Dermatology-Des Peres Med Arts Pavilion II

Interventional Study to Evaluate the Appearance of Surgical Scars After Laser Therapy

A Single Center, Double-blinded Randomized Placebo-controlled Trial to Evaluate Surgical Scars After Treatment With Fractional Carbon Dioxide Rejuvenation Laser Therapy

Utilizing the Vectra microtopographic imaging system, the study team will measure changes in the length of the scar after laser therapy.

Utilizing a scar assessment scale, the study will evaluate features of color change, thickness, width, texture of the scar, pain associated with the scar, and itching associated with the scar by the patient and blinded clinical evaluators.

Participants will be given a diary to record the severity and duration of symptoms for thirty days after each laser treatment: redness, swelling, burning sensation, post-inflammatory pigment changes, infection, scarring, dry skin, itching, bronzing, and any other adverse events that arise following treatment

De-identified participant data may be accessed after publication of the results in a medical journal.

vitiligo/otok

Microneedling for Acquired Hypomelanosis

Interventional Study to Evaluate the Appearance of Surgical Scars After Laser Therapy

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