[An analysis of the correlation between the indices of uterine-placental blood flow and the blood enzymes in pregnant women with high perinatal risk].

The purpose of the present study was to analyse correlation interactions between parameters of uterine-placental blood flow (UPF) and some enzymes of blood of 77 pregnant women with high risk of perinatal pathology, divided into 4 groups. Eleven correlation connections between parameters of blood flow and enzymes of blood were found in the first group of pregnant women without disturbance in UPF. In the pregnant women with a reduction in blood flow in the region of the large uterine-placental vessels there was dissociation of a large part of the aforementioned correlation connections as only 4 ware preserved (26.67%). New correlation connections occurred between oxytocinase and parameters of UPF. We found dissociation of all correlation connections between parameters of UPF and blood enzymes in the third group of pregnant women with a reduction of UPF in the whole uterine-placental blood flow. New correlation connections between alkaline and thermostable phosphatase in parameters of UPF were formed. Ten out of eleven correlation connections dissociated in the four group of pregnant women with a reduction of UPF only in the intervillous space. New correlation connections were formed between parameters of UPF and hydroxybutyrate dehydrogenase and lactate dehydrogenase. Having in mind the performed analysis of correlation interconnections between parameters of UPF and some blood enzymes we could assume that activation of various enzymic systems, forming links of adaptation-compensatory mechanisms of the placental system, occurs in the development of placental insufficiency.