Zhongguo zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban 2002-Jan

[Effect of Panax notoginseng saponins on human kidney fibroblast].

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Ying Wei

Jun-ming Fan

Li-ping Pan

ARTIKEL: 12585173

BioSeek: 12585173

Nyckelord

saponin

fibrosis

lungfibros

ginsengsläktet

panax notoginseng

Abstrakt

OBJECTIVE

To study the effect of Panax notoginseng saponins (PNS) on cell proliferation, type I collagen secretion and integrin beta 1 expression in human kidney fibroblast (KFB).

METHODS

KFB were cultured and stimulated by PNS in vitro. The cell proliferation, type I collagen secretion and integrin beta 1 expression in KFB were measured by methyl thiazolyl tetrazolium (MTT), enzyme-linked immunoabsorbent assay (ELISA) and flowcytometry respectively.

RESULTS

Within its optimal concentration range and effective time range, PNS could obviously inhibit the proliferation, type I collagen secretion and integrin beta 1 expression (all P < 0.05) in human KFB.

CONCLUSIONS

PNS would possibly be an effective drug for renal interstitial fibrosis prevention and treatment.