[Experimental studies on hypoglycemic effects of total flavonoid from Toona sinensis].

OBJECTIVE

To study hypoglycemic effects of total flavonoid from Toona sinensis (TSTF) on diabetic mice model.

METHODS

To confect alloxan 0.02 g/ml with NS and injected alloxan into abdominal cavity to induce diabetic model, and all rats were fed bid with glucose for 2 consecutive days, then the blood glucose was detected by glucose oxidizes, when hypoglycemic point >11.00 mmol/L the rats were successful model made. 100 model rats were divided into 5 groups as contrast groups (distilled water), model control control groups, hight doses group (0.12 g/kg) and low doses group (0.6 g/kg) of TSTF, positive control groups of phenformin (0.10 g/kg); In addition to set 20 natural rats (distilled water), and all groups were fed qd for 15 consecutive days, and then the blood glucose were detected by glucose oxidizes in the sixteenth day.

RESULTS

The blood glucose levels of the diabetic rats in TSTF groups significantly decreased.

CONCLUSIONS

TSTF can significantly decrease the blood glucose levels of diabetic mice induced by alloxan.