Orbit 2004-Dec
Growth factor receptor expression in orbital lymphangioma: possible therapeutic implications.
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Abstrakt
OBJECTIVE
To examine the expression of molecules targeted by imatinib mesylate (STI571;Gleevec) and epidermal growth factor receptor (EGFR) inhibitors in orbital lymphangiomas.
METHODS
Retrospective observational case series.
METHODS
Six patients with orbital lymphangioma treated at four institutions between March 2000 and December 2002.
METHODS
Tissue specimens and medical records from six patients were collected. Immunohistochemical analysis was performed using antibodies against c-kit and platelet-derived growth factor receptor (PDGFR) alpha and beta and EGFR tyrosine kinase.
