[Interaction of actinomycetes in relation to an intensification of protease biosynthesis].

This work was aimed at studying the interactions during the growth of Actinomyces rimosus producing proteases and Actinomyces violocinereus which did not synthesize secreted proteolytic enzymes. The production of proteases in the association of the actinomycetes was shown to be stimulated by metabolic products released by A. violocinereus into the surrounding medium. The stimulating agent from the cultural broth of this culture accelerated differentiation of the mycelium of the first hyphal generation in A. rimosus, decelerated spore formation of the second hyphal generation, inhibited the growth rate, and increased the rate of protease accumulation as well as the productivity of the synthesis.