Yao xue xue bao = Acta pharmaceutica Sinica 1991
[Studies on pyridonecarboxylic acids as anti-bacterial agents. IX. Study on prodrugs of some pyridonecarboxylic acids].
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Abstrakt
Synthesis and antibacterial activity of pivaloyloxymethyl esters of norfloxacin, ciprofloxacin and their N-substituted derivatives are reported. In vivo antibacterial activities (ED50) of IIIAa, b, e; IIIBa, e; IVA and IVB were 2.30, 8.48, 4.28, 2.77, 4.46, 5.68 and 0.75 (mg/kg) respectively.