Bioorganic and Medicinal Chemistry Letters 2008-Aug
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.
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Modification of the potent imidazole-based B-Raf inhibitor SB-590885 resulted in the identification of a series of furan-based derivatives with enhanced CNS penetration. One such compound, SB-699393 (17), was examined in vivo to challenge the hypothesis that selective B-Raf inhibitors may be of value in the treatment of stroke.