[The phylogenetic theory of general pathology. The development of seven biological functions, seven specific ones and etiological factors of metabolic epidemics, millions years' common pathogenesis and basics of prevention.]

The clearer realization is coming that in general biology, medicine, historical science, in biologic phylogenetic anamnesis of Homo sapiens a task exists only one by its significance and unresolved still: to establish historical succession of becoming of specific etiologic factors of every metabolic epidemic and to understand becoming of millions years' common pathogenesis of all metabolic pandemics. The carnivorous feeding by ocean, herbivorous feeding of ancestors of rodents and Homo sapiens by dry land; misusing carnivorous food by phylogenetically herbivorous human during last centuries, disorder of biological function of trophology, biological reaction of exotrophy, pathology of biologic functions of adaptation and endoecology, features of cognitive biological function formed etiological factors of atherosclerosis and atheromatosis. The abnormalities of biological reaction metabolism↔micro-circulation; discrepancy of mechanisms of regulation of biological reaction at 2d and 3d levels of relative biological perfection in vivo, disorder of biological function of adaptation, biological reaction of compensation formed etiological factors of metabolic arterial hypertension. The synthesis of fatty acids in phylogenesis millions of years before of glucose, preference of cells to absorb fatty acids instead of glucose; previously in phylogenesis effect of hyperglycemia, glucagon and late function of insulin formed priority of metabolism of fatty acids in energetics of organisms and glucose only in the second instance. The formation in phylogenesis of methodological mode of biological subordination in functioning of humoral mediators, incapability of insulin late in phylogenesis of blocking adaptive action of humoral mediators earlier in phylogenesis, especially in visceral fatty tissue form etiological factors of resistance to insulin. The functional limitation of cognitive biological function, difficulties in maintaining unity of internal medium of organism and effects of aphysiologic factors of external medium produces necessity of completing cognitive biological function with activation of biological reaction of apoptosis and autophagy. This occurrence forms etiologic factors of metabolic syndrome - a local pathology of early, visceral, limited in numbers of cells of pool of insulin-independent visceral fatty tissue. The inconsistency of cognitive biological function, necessity of correcting it by more effective biological function of intellect, role of insulin in energy support of new biological function - locomotion, formation of unlimited in numbers of cells а pool late in phylogenesis of insulin-dependent subcutaneous adipocytes, formed etiological factors of obesity. The biological function of depositing of fatty acids in phylogenesis in vivo is characterized by etiological dependence: depositing of fatty acids occurs in the form of non-polar triglycerides and releasing into intercellular medium occurs only in form of polar unesterified fatty acids. The features of induction with substrate, formation of positioning isoforms of fatty acids, impossibility of hydrolyzing them at effecting of hormone-dependent lipase compel to eliminate aphysiologic triglycerides from liver together with hepatocytes implementing biological reactions of apoptosis and autophagy. They become etiological factors of non-alcoholic fatty disease of liver; these are aphysiologic positioning iusoforms of triglycerides as palmitoyl-palmitol-palmitate and stearyl-stearyl-stearate. The formation of endogenous hyperuricemia in phylogenesis was initiated by 2 mutations. The first one - a gene of ascorbic acid "minus" deprived Homo sapiens of synthesis of hydrophilic acceptor of active forms of oxygen. The second one - a gene of uricase "minus" blocked synthesis of allantoin but provided a possibility of re-absorbing uric acid from a pool of primary urine and use it in vivo as an acceptor of active forms of oxygen instead of ascorbic acid under realization of biological function of endoecology,biologic reaction of inflammation.