Pharmacological Reports 2019-Nov
Cassia tora prevents Aβ1-42 aggregation, inhibits acetylcholinesterase activity and protects against Aβ1-42-induced cell death and oxidative stress in human neuroblastoma cells.
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METHOD
Ethyl acetate fraction of C. tora was purified by chromatography, characterized by 1H and 13C NMR, and tested for its ability to prevent Aβ 1-42 aggregation by thioflavin-T fluorescence and transmission electron microscopy. We also analyzed the intracellular ROS level and cytotoxicity in SK-N-SH and SH-SY5Y cell lines.RESULTS
The extract inhibits the formation of Aβ 1-42 aggregation from monomers and oligomers, as also acetylcholinesterase activity, Aβ 1-42 -induced cell death, and Aβ 1-42 -dependent intracellular ROS production in both SK-N-SH and SH-SY5Y cells. In-depth chromatographic and spectroscopic analysis of the extract revealed that the active molecules are most likely triglycerides of oleic acid (C18H34O2).CONCLUSION
We demonstrate for the first time that Cassia tora fraction prevents Aβ 1-42 aggregation, inhibits acetylcholinesterase and alleviates Aβ 1-42 -induced oxidative stress in human neuroblastoma cells. We further suggest the possible use of triglycerides of oleic acid as efficient anti-Alzheimer agents.