[Clinical Investigation in the Methods for Complete Placenta Previa Labor Induction in the Second Trimester]

Objective: To investigate the appropriate method of labor induction in the second trimester for complete placenta previa patients. Methods: The labor induction outcomes of 85 cases with complete placenta previa in the second trimester were retrospectively analyzed. Twenty patients in group A were treated with cesarean section, 30 patients in group B were treated with ethacridine and mifepristone combined with uterine artery embolization (UAE), and 35 patients in group C were induced by using ethacridine and mifepristone. The clinical features and induction outcomes of three groups were compared. Results: The total duration of labor in group B [(28.7±30.1) hours] was significantly longer than that of group C [(24.3±21.9) hours; P<0.05]. The total amount of blood loss during induction and labor in group B [(302±271) ml] was significantly lower than those of group C [(393±523) ml] and group A [(626±487) ml; P<0.05]. The incidence of fever in group B (13%, 4/30) was significantly higher than those of group C (11%, 4/35) and group A (10%, 2/20; P<0.05). In group C, 13 patients (37%, 13/35) underwent emergency UAE, and 2 patients (6%, 2/35) underwent emergency cesarean section. As to average hemoglobin level and blood transfusion rate, there were no difference among the three groups (all P>0.05). Conclusion: Prophylactic UAE combined with drug induction in patients with complete placenta previa in the second trimester could significantly reduce the amount of bleeding during induction and reduce the risk of emergency procedures.

目的： 探讨妊娠中期完全性胎盘前置状态孕妇的不同引产方式及其结局。 方法： 回顾性分析2011年1月1日至2019年1月1日广州医科大学附属第三医院收治的85例中孕期完全性胎盘前置状态引产孕妇的临床资料。根据引产方式不同分为3组：采用剖宫取胎术，为剖宫取胎组，20例；采用预防性子宫动脉栓塞术（UAE）+药物（依沙吖啶+米非司酮）引产，为UAE+药物引产组，30例；采用药物（依沙吖啶+米非司酮）引产，为药物引产组，35例。比较3组孕妇的临床特征及引产结局。 结果： UAE+药物引产组孕妇的引产时间[（28.7±30.1）h]较药物引产组[（24.3±21.9）h]长，两组比较，差异有统计学意义（P<0.05）；UAE+药物引产组引产时总的出血量[（302±271）ml]较药物引产组[（393±523）ml]及剖宫取胎组[（626±487）ml]显著减少，3组比较，差异有统计学意义（P<0.05）。UAE+药物引产组的发热率（13%，4/30）较药物引产组（11%，4/35）及剖宫取胎组（10%，2/20）高，3组比较，差异有统计学意义（P<0.05）。药物引产组中，有13例（37%，13/35）行急诊UAE，2例（6%，2/35）行急诊剖宫取胎术。3组孕妇引产前后血红蛋白变化水平、输血比例及输注红细胞量分别比较均无显著差异（P均>0.05）。 结论： 中孕期完全性胎盘前置状态孕妇行预防性UAE联合药物引产可显著减少引产总出血量，降低其引产时急诊手术的风险。.

Keywords: Labor, induced; Placenta previa; Pregnancy trimester, second; Uterine artery embolization.