Effect of Nicotine Dependence and Smoking on Revision Diskectomy After Single-Level Lumbar Diskectomy

Removal of a herniated disk that is causing neural compression is among the most common indications for spinal surgery. Previous population database studies of risk factors for reoperation after this procedure analyzed small to medium numbers of patients. To date, no study has concurrently assessed the effect of modifiable risk factors, such as smoking and nicotine dependence, with a large number of patients. Data were obtained with commercially available software that houses de-identified data for several major US health care systems. A database search was conducted to find all patients who had undergone lumbar diskectomy. Obesity, scoliosis, spondylolisthesis, and depression were excluded as possible confounding variables. The remaining patients were divided into smoking and nonsmoking groups. Those who had undergone revision lumbar diskectomy within 2 years were counted. Pearson's chi-square statistical test was used to determine significance at P<.05. Of the 50 million patient records in the software platform, 53,360 patients were identified who had undergone single-level lumbar diskectomy. Of these, 26,980 fulfilled the inclusion criteria. A total of 890 of those patients had undergone revision lumbar diskectomy within 2 years of their original procedure. Those who smoked were found to have a relative risk of 2.47 compared with nonsmokers (95% confidence interval, 2.17-2.82; P<.0001). Nicotine dependence and smoking had a significant effect on the rate of reoperation. These findings support the importance of preoperative assessment of modifiable risk factors and their effects on surgical complications. [Orthopedics. 2020;43(x):xx-xx.].