INFLUENCE OF PHYTOCOMPOSITIONS ON DYNAMICS OF CHANGES IN BASAL GLYCEMIA AND GLYCEMIA IN ORAL GLUCOSE TOLERANCE TEST IN RATS WITH STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETES MELLITUS TYPE 2.

Diabetes mellitus is one of the global medical, social and economic problems of today.Therefore, it is important to develop a new mechanism of action with fewer side effects that can reduce glycemia and insulin resistance. The aim of the study was to determine the effect of phytocompositions on the basis of Galega officinalis L. and Galevit in the conditions of therapeutic and prophylactic use in experimental type 2 diabetes mellitus contribute to the recovery of carbohydrate metabolism.on the dynamics of changes in basal glycemia and glycemia after oral glucose tolerance test in animals under conditions of experimental streptozotocin diabetes. The composition of the maturing phytocomposition and its lipocomposite form includes dry extract Galega officinalis L. - 50.0 mg, dry extract of Vaccinium myrtillus L. leaf - 50.0 mg, taurine - 1.4 mg. Type 2 diabetes mellitus was modeled on the method of Islam S., Choi H. 50 nonlinear white rats-males body weighing 180-220 g were used for the experimental studies.All animals were randomized into 5 groups of 10 rats: 1 - control group; 2 - animals with with T2DM; 3 - animals with diabetes mellitus, which received reference drugs (Arfa combi); 4 - STZ+N and substances received phytocomposition; 5 - STZ+N and Galevit. The investigated phytocompositions were administered intragastrically once a day for 28 days, starting 24 h after induction of type 2 diabetes mellitus. Phytocompositionson the basis of Galega officinalis L. and Galevit in the conditions of therapeutic and prophylactic use in experimental type 2 diabetes mellitus contribute to the recovery of carbohydrate metabolism. At the effectiveness of correction of metabolic changes, in experimental diabetes mellitus, phytocomposition based on Galega officinalis L. is not inferior, and liposomal form of dry extract Galevit is dominated by the reference phyto-agent Arfa combi. The spectrum of metabolic activity and the effectiveness of the therapeutic and prophylactic action of the application of the liposomal form of this phytocomposition under the conditional name Galevit is more justified on the basis of pathological changes, and the develo-pment of a new antidiabetic herbal remedy is more expedient.