Parkinson's Disease

NTCELL Implantation

Sham Surgery

Auckland City Hospital

Investigation of the Safety and Efficacy of NTCELL® [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients With Parkinson's Disease

A Phase IIb, Randomised, Double-blind, Placebo-controlled, Dose-range Investigation of the Safety and Efficacy of NTCELL® [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients With Parkinson's Disease

Adverse events can result from, for example, abnormal clinical laboratory tests (including xenogeneic viral analysis), abnormal physical examination findings, any abnormal findings following review by an infectious disease physician. These multiple assessments result in the one outcome measure which is the incidence of treatment emergent adverse events

International conference presentations, press releases, International journal publications

Living Cell Technologies

Statistecol Consultants Limited

NTCELL 40 microcapsules (+/- 20%)
The NTCELL microcapsules are drawn up into a catheter system and introduced intracranially by stereotactic insertion into the brain under guidance by neuroimaging.

NTCELL

Open-label Investigation of the Safety and Clinical Effects of NTCELL in Patients With Parkinson's Disease

A Phase I/IIa, Open-label Investigation of the Safety and Clinical Effects of NTCELL [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients With Parkinson's Disease

measured by the incidence of adverse events, clinical laboratory tests (including xenogeneic viral analysis), physical examination, review by infectious disease physician

TESTS USED
National Adult Reading Test
Speed and Capacity of Language Processing Test
Boston Naming Test
Trail Making Test A
Trail Making Test B
WMS IV Logical Memory I
WMS IV Logical Memory II
RAVLT List Learning
RAVLT Short Delay Recall
RAVLT Long Delay Recall
Rey Complex Figure Copy
Rey Complex Figure Delayed Recall
WAIS IV Digit Span
WAIS IV Matrix Reasoning
WAIS IV Symbol Search
WAIS IV Coding
DKEFS Word Fluency
DKEFS Category Fluency
DKEFS Category Switching
DKEFS Colour Naming
DKEFS Word Reading
DKEFS Inhibition
DKEFS Inhibition/switching
Mini Mental State Examination
Montreal Cognitive Assessment
HADS Anxiety
HADS Depression

Patients randomized to gatifloxacin (Zymar)

Patients randomized to moxifloxacin (Vigamox)

Patients randomized to ofloxacin (Ocuflox)

Patients randomized to azithromycin (AzaSite)

Age-related Macular Degeneration

Conjunctival and nasopharyngeal bacteria cultures

alginate/atrofi

Investigation of the Safety and Efficacy of NTCELL® [Immunoprotected (Alginate-Encapsulated) Porcine Choroid Plexus Cells for Xenotransplantation] in Patients With Parkinson's Disease

Open-label Investigation of the Safety and Clinical Effects of NTCELL in Patients With Parkinson's Disease

Antibiotic Resistant Patterns of Conjunctival and Nasophayngeal Flora After Repeated Exposure to Topical Antibiotics

A Randomized, Controlled Trial of Autologous Platelet Gel Treatment in Diabetic Foot Ulcers

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