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Biodegradable alginate microspheres as a delivery system for naked DNA.

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Sodium alginate is a naturally occurring polysaccharide that can easily be polymerized into a solid matrix to form microspheres. These biodegradable microspheres were used to encapsulate plasmid DNA containing the bacterial beta-galactosidase (LacZ) gene under the control of either the

[Experimental studies on adriamycin alginate-chitosan microcapsules in the treatment of rabbit VX2 carcinoma in the extremity].

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OBJECTIVE To study the effects of chemoembolization with adriamycin alginate-chitosan microcapsules in the treatment of VX2 carcinoma in the extremity of the rabbit. METHODS Twenty-four New Zealand white rabbits transplanted with VX2 carcinoma cells into the muscle tissue of the lower right thigh

Improved function of microencapsulated hepatocytes in a hybrid bioartificial liver support system.

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Conventional methods of microencapsulating isolated hepatocytes with Type I collagen matrix have provided metabolic liver support in experimental animal models of acute liver failure and congenital metabolic liver disease. We compared the biological function of transplanted microencapsulated

Glycans with Antiviral Activity from Marine Organisms.

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There remains today a critical need for new antiviral agents, particularly in view of the alarming increase in drug resistance and associated issues. The marine environment has been a prolific contributor towards the identification of novel therapeutic agents in the recent few decades. Added to

Sequentially dual-targeting vector with nano-in-micro structure for improved docetaxel oral delivery in vivo.

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OBJECTIVE In this study, we constructed a novel vector (BioPf-M-loaded Alg-microparticles [Alg-BioPf-M]) with nano-in-micro structure to improve the oral absorption of docetaxel (DTX) by sequentially dual-targeting functions toward intestine and sodium-dependent multivitamin transporter based on

Morphological changes of epithelial rests of Malassez in rat molars induced by local administration of N-methylnitrosourea.

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The objective was to examine the possibility that epithelial rests of Malassez can give origin to odontogenic tumours. A mixture of N-methylnitrosourea (MNU) and alginate impression material for dental use was injected onto the periosteum of the buccal side of the left mandible of 5-week-old, male

The tumoricidal potential of extracorporeal shock wave therapy.

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A potential role of extracorporeal shock wave lithotripsy (E.S.W.L.), in the destruction of tumours has been proposed in recent literature. To examine further this potential, we have studied the effects of E.S.W.L. on the sarcoma-derived osteoblast-like cell line MG-63. An in-situ assay of cell

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