anti aging/stroke

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Bioidentical hormones, menopausal women, and the lure of the "natural" in U.S. anti-aging medicine.

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In 2002, the Women's Health Initiative, a large-scale study of the safety of hormone replacement therapy (HRT) for women conducted in the United States, released results suggesting that use of postmenopausal HRT increased women's risks of stroke and breast cancer. In the years that followed, as

Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging Properties with a Special Emphasis on Studies with LPS and Argan Oil as a Model Transposable to Aging.

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To clarify appropriateness of current claims for health and wellness virtues of argan oil, studies were conducted in inflammatory states. LPS induces inflammation with reduction of PGC1-α signaling and energy metabolism. Argan oil protected the liver against LPS toxicity and interestingly enough

The antiaging activity and cerebral protection of rapamycin at micro-doses.

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OBJECTIVE The immunosuppressant drug rapamycin was reported to have an antiaging activity, which was attributed to the TORC1 inhibition that inhibits cell proliferation and increases autophagy. However, rapamycin also exhibits a number of harmful adverse effects. Whether rapamycin can be developed

Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip.

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C. elegans is widely used as a model organism in the study of aging and evaluation of anti-aging drugs due to its unique characteristics. In this work, we set out to investigate polydatin, a natural resveratrol glycoside, and its role in extending lifespan, improving oxidative stress resistance, and

Imaging of acute stroke: state of the art.

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The high incidence of stroke, plus its fatal or debilitating outcome, has prompted tremendous advances over the last two decades on both diagnostic and therapeutic fronts. Multiple randomized trials have proven the utility of thrombolytic agents with rejuvenation of the role of diagnostic imaging.

Age-dependence of sensorimotor and cerebral electroencephalographic asymmetry in rats subjected to unilateral cerebrovascular stroke.

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BACKGROUND The human population mostly affected by stroke is more than 65 years old. This study was designed to meet the recommendation that models of cerebral ischemia in aged animals are more relevant to the clinical setting than young animal models. Until now the majority of the pre-clinical

Rejuvenation of aged pig facial skin by transplanting allogeneic granulocyte colony-stimulating factor-induced peripheral blood stem cells from a young pig.

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Following a stroke, the administration of stem cells that have been treated with granulocyte colony-stimulating factor (GCSF) can ameliorate functional deficits in both rats and humans. It is not known, however, whether the application of GCSF-mobilized peripheral blood stem cells (PBSCs) to human

Nitrones as neuroprotectants and antiaging drugs.

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Specific nitrones have been used for more than 30 years in analytical chemistry and biochemistry to trap and stabilize free radicals for the purpose of their identification and characterization. PBN (alpha-phenyl-tert-butyl nitrone), one of the more widely used nitrones for this purpose, has been

Reduced ischemic brain injury by partial rejuvenation of bone marrow cells in aged rats.

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Circulating bone marrow-derived immature cells, including endothelial progenitor cells, have been implicated in homeostasis of the microvasculature. Decreased levels of circulating endothelial progenitor cells, associated with aging and/or cardiovascular risk factors, correlate with poor clinical

Vaginal rugation rejuvenation (restoration): a new surgical technique for an acquired sensation of wide/smooth vagina.

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BACKGROUND No paper on vaginal columnar rugation rejuvenation has been published so far. OBJECTIVE To evaluate a new surgical technique of vaginal rugae restoration for the management of an acquired sensation of wide/smooth vagina (ASWSV). METHODS A prospective observational study was conducted. Ten

Associations between serum selenium and total plasma homocysteine during the acute phase of ischaemic stroke.

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OBJECTIVE Risk of ischaemic stroke (IS) was associated with total homocysteine (tHCY). On the other hand, serum selenium (Se) exhibited anti-aging and cardiopreventive effects. Se and tHCY showed relationships in animals but these were contradictory or inconclusive in humans; therefore, we searched

"I'm Going to Stay Young": Belief in Anti-Aging Efficacy of Menopausal Hormone Therapy Drives Prolonged Use Despite Medical Risks

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Background: Over a third of menopausal hormone therapy (HT) prescriptions in the US are written for women over age 60. Use of HT more than 5 years is associated with increased risk for cardiovascular disease; breast, ovarian, and endometrial cancers; thromboembolic

Serum-mediated Activation of Bone Marrow-derived Mesenchymal Stem Cells in Ischemic Stroke Patients: A Novel Preconditioning Method.

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Stroke induces complex and dynamic, local and systemic changes including inflammatory reactions, immune responses, and repair and recovery processes. Mesenchymal stem cells (MSCs) have been shown to enhance neurological recovery after stroke. We hypothesized that serum factors play a critical role

Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke.

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OBJECTIVE Ischemic stroke is a destructive cerebrovascular disease and a leading cause of death. Yet, no ideal neuroprotective agents are available, leaving prevention an attractive alternative. The extracts from the fruits of Lycium barbarum (LBP), a Chinese anti-aging medicine and food supplement,

Near 10-year and longer periods modulate circadians: intersecting anti-aging and chronoastrobiological research.

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Biological cycles with relatively long and some unusual periods in the range of the half-week, the half-year, years, or decades are being discovered. Their prior neglect constituted a confounder in aging and much other research, which then"flew blind" concerning the uncertainties associated with

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