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BACKGROUND OF THE INVENTION
The present invention relates to a series of compounds which are characterised by a 2-[2-(substituted phenyl-oxy, thio or methyl)-1-methylethyl]aminoethanol structure and which have valuable anti-diabetic and anti-obesity activities; in addition, they are capable of
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BACKGROUND TO THE INVENTION
The present invention relates to a series of compounds which are characterised by a 2-[2-(substituted phenyl-oxy, thio or methyl)-1-methylethyl]aminoethanol structure and which have valuable anti-diabetic and anti-obesity activities; in addition, they are capable of
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TECHNICAL FIELD
The present invention relates to a peptide having anti-obesity and/or anti-diabetic activities and including an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, a pharmaceutical composition for prevention and/or treatment of obesity and/or diabetes, the pharmaceutical composition
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BACKGROUND OF THE INVENTION
The major function of the adrenal gland is to regulate metabolism in the body so that an intermittent intake of food can be regulated to maintain a constant metabolite supply to the cells. This is accomplished by producing steroid hormones which can control the conversion
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FIELD OF THE INVENTION
The present invention relates to novel substituted acid derivatives which modulate triglyceride levels, lipid levels, blood glucose levels, insulin levels, and non-esterified fatty acid (NEFA) levels, and thus are particularly useful in the treatment of atherosclerosis,
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BACKGROUND OF THE INVENTION
The present invention provides novel compounds. More particularly, the present invention provides novel .alpha.-amino-indole-3-acetic acids, tryptophans and their derivatives. The compounds are useful as anti-diabetic, anti-obesity and anti-atherosclerotic
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CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 371 of PCT/KR2009/005970 filed on Oct. 16, 2009, which claims the benefit of Korean Patent Application No. 10-2008-0101932 filed on Oct. 17, 2008, the contents of each of which are incorporated herein by reference.
TECHNICAL FIELD
The
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FIELD OF THE INVENTION
This invention relates to a method for the preparation of certain biaryl derivatives.
BACKGROUND OF THE INVENTION
Atypical beta-adrenoceptors are known to occur in adipose tissue and the gastrointestinal tract. Atypical beta-adrenoceptor agonists have been found to be
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FIELD OF THE INVENTION
The present invention relates to a method for treating obesity, insulin resistance and dyslipidemia in mammals including humans through inhibition of PPAR.delta.(.beta.). This invention also relates to methods of screening for chemical entities that act to regulate
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This invention relates to compounds of the formula ##STR2## wherein R is secondary alkyl of 3 to 7 arbon atoms or tertiary alkyl of 4 to 7 carbon atoms,
R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,
R.sub.1 is primary or secondary alkyl of 1 to 5 carbon
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BACKGROUND OF THE INVENTION
Diabetes refers to a disease process derived from multiple causative factors and characterized by elevated levels of plasma glucose or hyperglycemia. Uncontrolled hyperglycemia is associated with increased and premature mortality due to an increased risk for microvascular
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a non-provisional application related to provisional application nos. 60/011,094 filed on Feb. 2, 1996 and 60/034,433 filed on Dec. 23, 1996, priority of which is claimed hereunder.
BACKGROUND OF THE INVENTION
Diabetes refers to a disease
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FIELD OF THE INVENTION
The field of the invention is the use of tocopherols and tocotrienols in anti-obesity medicaments.
BACKGROUND OF THE INVENTION
Vitamin E consists of eight compounds; four tocopherols (alpha-, beta-, gamma-, and delta-) and four tocotrienols (alpha-, beta-, gamma-, and delta-).
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FIELD OF THE INVENTION
The present invention relates to compounds for use as medicaments, especially normoglycemic agents, i.e. for lowering blood glucose levels to normal levels in mammals that are obese, pre-diabetic or have diabetes, obesity and/or syndrome X.
BACKGROUND OF THE INVENTION
Diabetes
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This application is a National Stage Application of PCT/EP2010/065052, filed 7 Oct. 2010, which application is incorporated herein by reference. To the extent appropriate, a claim of priority is made to the above disclosed application.
FIELD OF THE INVENTION
The present invention relates to
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