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Antidote to cannabinoid intoxication: the CB1 receptor inverse agonist, AM251, reverses hypothermic effects of the CB1 receptor agonist, CB-13, in mice.

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OBJECTIVE Cannabis is a recreational drug leading to intoxication, following stimulation of cannabinoid CB1 receptors. However, more recently, herbs mixed with synthetic cannabinoids sometimes known as 'Spice' and 'Black Mamba' have been increasingly used, and their high CB1 receptor affinity has

A cannabinoid-intoxicated child treated with dexmedetomidine: a case report.

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BACKGROUND In the last 20 years, the rate of exposure to marijuana has increased dramatically, even in the pediatric population. Effects of intoxication are variable, more severe neurological symptoms can be observed following ingestion, thus hospital or intensive care unit admission is often

A New Differential Diagnosis: Synthetic Cannabinoids-Associated Acute Renal Failure.

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Synthetic cannabinoids (SCs) are herbal blends that use plant material with varying concentrations of synthetic analogues of cannabinoids. These products are sold as incense or potpourri and are labeled "Not for human use." Even so, rates of abuse are rapidly increasing worldwide, especially in the

Models to predict cannabinoid-induced disturbances.

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The most commonly used animal models to evaluate the psychoactivity of cannabinoids have been reviewed. The need for suitable models is acute considering the present interest to develop drugs based on the cannabinoid moiety but preferably dissociated from psychoactivity. Conceivably, a satisfactory

A case of synthetic cannabinoid poisoning in Croatia.

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The number of new psychoactive substances (NPS), synthetic cannabinoids (SCs) in particular, is growing constantly. Because of the insufficiently explored effects on consumer health, they have become a major problem in the emergency departments. They are difficult to identify, and there are no

[Bonzai, lead and bath salt-poisoning with new and old drugs : Synthetic amphetamines, cathinones, cannabinoids and opioids-an overview].

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BACKGROUND There has been an increase in the number of serious poisonings and deaths after the use of new psychoactive substances (NPS). These are usually bought online: sometimes legally, often illegally or "in the grey area". OBJECTIVE Characteristics of different NPS. Legal status concerning the

Emerging drugs of abuse: current perspectives on synthetic cannabinoids.

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New psychoactive drugs that have appeared over the last decade are typically dominated by cathinones and synthetic cannabinoids (SCs). SCs have been emerging as recreational drugs because they mimic the euphoria effect of cannabis while still being legal. Sprayed on natural herb mixtures, SCs have

Intravenous Lipid Emulsion Therapy for Acute Synthetic Cannabinoid Intoxication: Clinical Experience in Four Cases.

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There is no specific antidote for intoxication with synthetic cannabinoids. In this case series, we considered the efficiency of intravenous lipid emulsion therapy in four cases, who presented to emergency department with synthetic cannabinoid (bonzai) intoxication. The first patient had a GCS of 3

Cannabinoids in the management of severe nausea and vomiting from cancer chemotherapy. Some additional considerations.

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Although the cannabinoids are effective antidotes to the nausea and vomiting produced by cancer chemotherapy, they also have other properties that may be of therapeutic value. These should be explored. The possibility of interactions, both useful and harmful, between the anticancer drugs and other

Marijuana poisoning.

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The plant Cannabis sativa has been used for centuries for the effects of its psychoactive resins. The term "marijuana" typically refers to tobacco-like preparations of the leaves and flowers. The plant contains more than 400 chemicals but the cannabinoid δ-9-tetrahydrocannabinol (THC) is the major

Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects.

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Tetrahydrocannabinol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it. More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated. Other

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