The present invention provides a pharmaceutical composition comprising an aqueous solution of arginine and ibuprofen, wherein the molar ratio of arginine to ibuprofen is less than 1:1, as well as a method of making the same. The present invention also provides a method of treating a condition chosen from pain, inflammation, fever, and/or other conditions alleviated by ibuprofen comprising administering a pharmaceutical composition comprising an aqueous solution of arginine and ibuprofen, wherein the molar ratio of arginine to ibuprofen is less than 1:1.

Cumberland Pharmaceuticals Inc.

Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid

The invention relates to an oral pharmaceutical composition comprising the combination of an ibuprofen salt or S(+)-ibuprofen with L-arginine and/or the pharmaceutically acceptable salts thereof, and additionally pharmaceutically acceptable vehicles and/or excipients. The invention also relates to the method of producing the composition and to the use of said composition having synergic therapeutic activity, for treating moderate to severe inflammatory pain, fever and inflammation.

Senosiain Pelaez; Juan Pablo

Arzola Paniagua; Angelica

Garcia-Salgado Lopez; Enrique Ra l

LABORATORIOS SENOSIAIN S.A. DE C.V.

Combination of an NSAID and an amino acid

A novel pharmaceutical formulation includes a four mg per ml (4 mg/mL) Ibuprofen in an aqueous solution of Arginine and Ibuprofen, wherein the molar ratio of Arginine to ibuprofen is more than or equal to 1.000625:1, Tris buffered, isotonic, and adjusted to pH between 7.2-8.5 by addition of 1.0 N HCL, none of the excipients used contains material of animal or human origin. There were no novel excipients used. A method of treating through anti-inflammatory, analgesic, and antipyretic activity: fever, pain, dysmenorrhea and inflammatory diseases are also described. It is also used for pericarditis and patent ductus arteriosus (Patent ductus arteriosus (PDA)), relieve moderate to severe pain, dental pain and pain after an operation, mild to moderate pain including migraine headache, and for short term treatment of pyrexia in children over one year of age. The formulation is meant to be used as ready to use intravenous infusion.

Pharmaceutical Solutions Industry Ltd.

PHARMACEUTICAL SOLUTIONS INDUSTRY LTD.

Ibuprofen intravenous infusion

The combination of N.sup..alpha.-long chain alkanoyl di basic amino acid alkyl ester salts with glycerol monofatty acid esters results in biocidal synergy and the extension of cidal activity of the di basic amino acid derivative for a variety of antimicrobial applications like oral care, wound care, dermatological care, animal care, and cosmetic applications. N.sup..alpha.-C8-C14-long chain alkanoyl-L-arginine alkyl (C1-C4 short chain) ester salts with glycerol monofatty acid esters (C8-C14) are very effective as antimicrobial agents for hospital use particularly as a coating for surgical drapes, covers, walls, trays, table tops, gurneys, or the like. Other uses include the treatment of HSV-1 (fever sore) and as a microbicide when using the combination of the di basic amino acid ester derivative with glycerol monofatty acid esters for preventing HIV and STD's.

arginine/feber

Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid

Combination of an NSAID and an amino acid

Ibuprofen intravenous infusion

Antimicrobial agents

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