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Sida 1 från 31 resultat
Influence of Rivaroxaban for Intermittent Claudication and Exercise Tolerance in Patients With Symptomatic PAD
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EXISTING KNOWLEDGE AND MAIN ASSUMPTIONS OF THE PROJECT.
Atherosclerosis is the most common cause of peripheral artery disease (PAD). The first symptom of PAD is intermittent claudication (IC), which is characterized by the occurrence of pain, cramps, numbness, and discomfort in the lower limb
The Acute and Chronic Effects of Remote Ischemic Conditioning on Cardiovascular Function
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The present study is a prospective, randomized trial conducted at the Second University Department of Cardiology in Attikon University Hospital. A two hundred seventy patients with STEMI , within 48 hours after primary PCI are randomized in two remote conditioning (RIC) protocols or no intervention
Vascular Functions in Myeloma Patients During Anti-tumor Therapy
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Treatment options for multiple myeloma have increased significantly over the last years with the approval of immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). These therapies have markedly improved overall survival for these patients to a median of 5-7 years, many continue to live for
Trauma Screening and Supplementation
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Following consent, patients will be assigned a unique study identification number (ID). A master list linking patient ID to patient name and medical record number will be maintained on a password protected and encrypted departmental server location with access limited to research staff. Patients
Glycemic Control and Endothelial Function in Patients With Type 2 Diabetes
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The study is performed on one group of patients with type 2 diabetes and one group of age-matched healthy controls
Inclusion criteria:
1. Type 2 diabetes
2. Poor glycaemic control defined as a mean day blood glucose >12 mmol/L.
Exclusion criteria:
1. Age >80 years.
2. HbA1c <70 mmol/mol
3.
Biomarker for Homozygous Familial Hypercholesterolemia (BioHoFH)
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Homozygous familial hypercholesterolemia (HoFH) is a rare hereditary disorder of lipoprotein metabolism characterized by exceptionally high levels of low-density lipoprotein cholesterol (LDL-C). Clinical manifestations may vary but often include markedly premature coronary artery disease,
Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity
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Atherosclerosis is the underlying cause of cardiovascular diseases (CVD), the major cause of death worldwide. Atherosclerosis is an inflammatory disease of the arteries in which activated macrophages are abundant in the atherosclerotic lesions. Macrophages play key roles during early atherogenesis.
Prognostic Value of Copeptin for Infarct Size and Prognosis in Patients With ST-elevation Myocardial Infarction
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Acute myocardial infarction (AMI) is a major concern in public health in China. Ischemia/reperfusion injury cripples the treatment effect of reperfusion management, and increases the final myocardial infarct size. Copeptin is related to the prognosis of heart failure and AMI, and may be a potential
High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure
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Congestive heart failure (CHF) is common and currently affects an estimated 6.6 million adults in the United States (1). In addition being highly prevalent, CHF is responsible for ~ 1 million hospital discharges per year and approximately 50% of patients with CHF will die within 5 years making it a
Arginase Inhibition in Ischemia-reperfusion Injury
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Background: Arginase competes with nitric oxide synthase for their common substrate L-arginine. Up-regulation of arginase in coronary artery disease (CAD) and diabetes mellitus may reduce nitric oxide bioavailability contributing to endothelial dysfunction and ischemia-reperfusion injury. Arginase
Impact of Arterial Stiffness and Central Aortic Blood Pressure on Kidney Transplant Outcomes.
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Chronic kidney disease (CKD) is a significant public health problem in United States, particularly in southern states like Louisiana. People with CKD and end-stage renal disease (ESRD) have a poor survival compared with general population, and this is primarily due to a higher prevalence of
Study of Stroke Related Edema Treatments
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Previous work has demonstrated the pathophysiological role of arginine-vasopressin (AVP) in ischemic stroke. The mechanism of action of AVP is by 3 receptor subtypes: V1a, V1b and V2 expressed in brain, pituitary gland, myocardium, vasculature and kidneys. The role of the vasopressin receptors V1a
Effects of Repetitive Transcranial Magnetic Stimulation in the Treatment of Phantom Limb Pain in Landmine Victims: ANTARES
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Background In 2007 Colombia was one of the five countries in the world with the highest number of anti-personnel landmine victims [1]. These are small devices designed to injure or kill people and animals by exploding when a minimum pressure is exerted on them (approximately 6 Force-Kg) [2]. Between
Angiogenesis and Fibrosis in Aortic Stenosis
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Integrins
Integrins are a group of molecules responsible for intercellular adhesion and signalling. They comprise a superfamily of heterodimeric receptors that are composed of 18 different α and β subunits. In combination, they can generate 24 different receptor subtypes with a range of
Angiogenesis and Fibrosis in Myocardial Infarction
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Integrins are a group of molecules responsible for intercellular adhesion and signalling. They comprise a superfamily of heterodimeric receptors that are composed of 18 different α and β subunits. In combination, they can generate 24 different receptor subtypes with a range of physiological and
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