The first patient will receive 200 mg Artesunate once-daily for 14 days. If no dose-limiting toxicity (DLT) is observed after 14 days, the next patient will start at a daily dose of 300 mg Artesunate. If no DLT is observed after 14 days, a cohort of 3 patients will receive 400 mg once-daily for 14 days. For each subsequent cohort of 3 patients 200 mg will be added to the dose, until the maximum tolerated dose (MTD) is determined.

Hepatocellular Carcinoma

Oral Artesunate once-daily for 14 days, dose-escalation

Artesunate

Dept. of Hepatology & Gastroenterology, Ghent University

Dept. of Hepatology & Gastroenterology Ghent University Hospital

Dose-Escalation Study Evaluating the Safety and Pharmacokinetics of Artesunate in Patients With Hepatocellular Carcinoma

Phase I Dose-Escalation Study Evaluating the Safety and Pharmacokinetics of Oral Artesunate (ART) in Patients With Advanced Hepatocellular Carcinoma (HCC).

University Hospital, Ghent

University Ghent

Anticancer Fund, Belgium

A series of moxibustion sessions within six weeks from baseline with adjuvant chemotherapy.

Participants who will be allocated to waitlist will receive no moxibustion treatments throughout the 6 weeks while receiving adjuvant chemotherapy

Cancer

In the moxibustion treatment group, 3 moxibustion, 3 acupoints(CV12, CV8, CV54) will be heated with indirected moxibustion.
The moxibustion will be removed when the patient feel hotness and require remove them

Moxibustion

Click here for more information about this study:A Pilot study to estimate the efficacy of moxibustion stimulation at abdominal acupoints on quality of life in cancer patients

Deagu Hanny University Medical center

Impact on Quality of Life by Moxibustion in Chemotherapy for Cancer

A Pilot Study to Estimate the Efficacy of Moxibustion Stimulation at Abdominal Acupoints on Quality of Life in Cancer Patients Under Chemotherapy

lymphocyte panel(CD3,4,8,19,26), WBC, Differential count

Hyun jung, Jung

assistant professor

The Comprehensive and Integrative Medicine Institute of South Korea

Idiopathic Osteoarthritis

Treatment group received moxibustion treatment three times a week for 4 consecutive weeks, totally 12 sessions of treatment in addition to usual care to manage their knee OA.
Moxibustion points include six local acupuncture points on affected knee joint. Up to two additional tender points will be allowed, if necessary. If participants feel knee pain on both knee joints, study practitioners will provide treatment on both knee.
We will use smokeless indirect moxibustion made of wormwood with a diameter of 1.9 centirmeter and a length of 2.1 centimeter in a cylindrical form for this study (Haitnim Bosung Inc, Korea). Free participant-practitioner interaction will be allowed during the treatment session. Expected total time of each treatment session will be 40 - 60 minutes.

Moxibustion treatment plus usual care

Usual care alone group can receive or use any kind of treatment other than moxibustion treatment provided as study intervention, which includes surgery, conventional medication, physical treatment, acupuncture, herbal medicine, over-the-counter drugs and other active treatment. This also applies to the moxibustion treatment group.
Education material of information on knee osteoarthritis and current management option and self-exercise sheet with a yoga-mat to enhance regular exercise will be provided in both groups at baseline.

Usual care alone group

Daejeon University Hospital

Moxibustion for Knee Osteoarthritis

Moxibustion for Knee Osteoarthritis: a Randomized Pilot Clinical Trial

The primary outcome is the knee pain measured by WOMAC pain subscale at 4 weeks from baseline.

Practitioners and participants will evaluate the improvement of knee joint symptoms after treatment. They can chose one of the following 5 grades: Excellent, Good, Fair, Poor and Aggravation.

artemisia fukudo/neoplasms

Dose-Escalation Study Evaluating the Safety and Pharmacokinetics of Artesunate in Patients With Hepatocellular Carcinoma

Impact on Quality of Life by Moxibustion in Chemotherapy for Cancer

Moxibustion for Knee Osteoarthritis

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