aspartic acid/inflammation

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Derivatives of aspartic acid and glutamic acid having anticholecystokinin activity

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This invention relates to amino acid derivatives, and more particularly to amino acid derivatives which possess anti-cholecystokinin activity. The invention also relates to methods for preparing such cholecystokinin antagonists and to compounds which are useful as intermediates in such

Gene/carrier complex for preventing or treating inflammatory diseases

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SEQUENCE STATEMENT Incorporated by reference herein in its entirety is the Sequence Listing entitled "G18U10C0390PUS_ST25," created Oct. 29, 2018, size of 5 kilobyte. BACKGROUND 1. Field of the Invention The prevent invention relates to a gene/carrier complex for preventing or treating inflammatory

Anti-inflammatory peptides, and uses thereof

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CROSS REFERENCE TO RELATED APPLICATIONS This application is a 371 National Phase Entry of International Patent Application No. PCT/EP2016/067090 filed on Jul. 18, 2016 which claims benefit under 35 U.S.C. .sctn. 119(b) of EP Application No. 15177013.8 filed Jul. 16, 2015 and EP Application No.

Peptides which stimulate the expression of the cytokines of inflammation and promote tissue regeneration

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FIELD OF THE INVENTION This invention concerns a new family of peptide molecules having the capacity especially of stimulating the expression of the cytokines of inflammation and promoting regeneration of tissues. The invention, thus, also pertains to pharmaceutical compositions containing at least

5-aminosalicylic acid derivatives for the therapy of chronic inflammatory bowel diseases

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The invention refers to 5-aminosalicylic acid (5-ASA) derivatives of general formula 1 ##STR1## wherein R.sub.1 is hydrogen, glutamyl (Glu) or aspartyl (Asp) and R.sub.2 is OH or the residue leucyl-prolyl, with the proviso that R.sub.1 and R.sub.2 cannot be contemporaneously hydrogen and hydroxy,

Sulfonamide substituted aspartic acid interleukin-1.beta. converting enzyme inhibitors

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FIELD OF THE INVENTION This invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme. This invention also relates to a method of treatment of stroke, inflammatory diseases, septic shock, reperfusion injury, Alzheimer's disease, shigellosis, and to a

Engineered botulinum neurotoxin

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BACKGROUND OF THE INVENTION Clostridium botulinum produces seven different neurotoxins (BoNTs) which differentiated serologically by the lack of anti-serum cross serotype neutralization. BoNTs are the most potent toxins known to humans and are the causative agents of the disease botulism (1). BoNTs

Pipecolic acid derivatives of proline threonine amides useful for the treatment of rheumatoid arthritis

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FIELD OF THE INVENTION Non-peptidic compounds are described for treatment of autoimmune diseases. Of particular interest are pipecolic acid derivatives compounds incorporating a characterizing segment condensed from pipecolic acid, aspartic acid, proline and threonine, or derivatives thereof, which

Orally administered small peptides synergize statin activity

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FIELD OF THE INVENTION This invention relates to the field of atherosclerosis. In particular, this invention pertains to the identification of a class of peptides that are orally administrable and that ameliorate one or more symptoms of atherosclerosis. BACKGROUND OF THE INVENTION Cardiovascular

Antioxidant composition

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CROSS-REFERENCE TO RELATED APPLICATIONS This application is a National Stage application of PCT/JP2010/055842, filed Mar. 31, 2010, which claims priority from Japanese application JP 2009-224742, filed Sep. 29, 2009. TECHNICAL FIELD The present invention relates to an antioxidant composition which

Amide derivatives of p-isobutyl-phenyl-propionic acids and related pharmaceutical compositions

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The present invention relates to amide derivatives of p-isobutyl-phenyl-propionic acid, having general formula: ##STR2## wherein X represents the radical of a substituted amine selected amongst lysine, metatrifluorotoluidine, glutamic acid and aspartic acid. The anti-inflammatory properties of

Synthetic polyunsaturated fatty acid analogues

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The present invention relates to new polyunsaturated fatty acids having antimalarial activity and/or neutrophil stimulatory activity. In addition, certain of the new polyunsaturated fatty acids depress cytokine activity. Over half of the world's population is at risk from malaria, with about 500

Glycopeptide compositions

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FIELD OF THE INVENTION The present invention relates to glycopeptide compositions containing a glycoside and a peptide and their uses as biomaterials. Specific embodiments relate to chitosan-based glycopeptides. More specific embodiments relate to glycopeptides including chitosan and poly(amino

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