asthenia/inflammation

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In the idiopathic inflammatory myopathies (IIM), do reactive oxygen species (ROS) contribute to muscle weakness?

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The idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune disorders, collectively known as myositis. Affected patients present with proximal muscle weakness, which usually improves following treatment with immunosuppressants, but often incompletely so, thus many patients remain

Muscle and nerve inflammation in intensive care unit-acquired weakness: a systematic translational review.

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BACKGROUND Intensive care unit-acquired weakness (ICU-AW) is an important complication of critical illness. The main risk factors, sepsis and the systemic inflammatory response syndrome, suggest an inflammatory pathogenesis. In this systematic translational review we summarize current knowledge on

Familial myopathies with restricted distribution, facial weakness and inflammatory changes in affected muscles.

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A myopathy characterized by restricted involvement of few muscles and inflammatory cell infiltration was observed in three families. In the first family, clinical features, hereditary transmission and biopsy findings were consistent with the diagnosis of facioscapulohumeral dystrophy. However in

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy.

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OBJECTIVE It is generally believed that muscle weakness in patients with polymyositis and dermatomyositis is due to autoimmune and inflammatory processes. However, it has been observed that there is a poor correlation between the suppression of inflammation and a recovery of muscle function in these

Skeletal muscle weakness caused by carrageenan-induced inflammation.

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BACKGROUND The skeletal muscle weakness associated with many chronic diseases has been attributed to the catabolic effect of pro-inflammatory cytokines. We aimed to determine if local muscle inflammation has direct affects on contractile function and contributes to muscle weakness independent of

Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness.

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OBJECTIVE Inflammation and immobility are comorbid etiological factors inducing muscle weakness in critically ill patients. This study establishes a rat model to examine the effect of inflammation and immobilization alone and in combination on muscle contraction, histology, and acetylcholine

The role of inflammation in ICU-acquired weakness.

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A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW. While this

Quantitative grip force assessment of muscular weakness in chronic inflammatory demyelinating polyneuropathy.

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In patients suffering from Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) disease severity is assessed by Medical Research Counsil (MRC) Scale or Inflammatory Neuropathy Cause and Treatment (INCAT) disability score. However, none of these methods is appropriate to objectively

Inflammatory cells, motor weakness, and straight leg raising in transligamentous disc herniations.

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METHODS Possible statistically significant relationships between inflammatory cells and either motor weakness or straight leg raising were determined. OBJECTIVE To look for any clinically relevant links between inflammatory cells in disc herniations and signs of radiculopathy. BACKGROUND Many

Proprioception mediates the association between systemic inflammation and muscle weakness in patients with knee osteoarthritis: results from the Amsterdam Osteoarthritis cohort.

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OBJECTIVE To determine whether systemic inflammation is associated with poor proprioception; to confirm that systemic inflammation is associated with muscle weakness; and to determine whether poor proprioception mediates the association between systemic inflammation and muscle weakness in knee

Understanding the origin of non-immune cell-mediated weakness in the idiopathic inflammatory myopathies - potential role of ER stress pathways.

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OBJECTIVE Discussion of endoplasmic reticulum (ER) stress pathway activation in idiopathic inflammatory myopathies (IIM), and downstream mechanisms causative of muscle weakness. RESULTS In IIM, ER stress is an important pathogenic process, but how it causes muscle dysfunction is unknown. We discuss

Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee.

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OBJECTIVE Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the in vivo effects of muscle weakness, joint inflammation and the combination

[Determination of a vector of therapy for weakness in incurable breast cancer patients based on the level of inflammatory response].

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The weakness is one of the negative factors that degrade cancer patients’ quality of life. The nature of weakness may be multifactorial but among mechanisms of development of weakness a syndrome of chronic inflammation plays a crucial role. Therapy aimed at reducing of inflammation degree allows

A case study of gait compensations for hip muscle weakness in idiopathic inflammatory myopathy.

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BACKGROUND The purpose of this case series was to quantify different strategies used to compensate in gait for hip muscle weakness. METHODS An instrumented gait analysis was performed of three females diagnosed with idiopathic inflammatory myopathies and compared to a healthy unimpaired subject.

Length-dependent weakness and electrophysiological signs of secondary axonal loss in chronic inflammatory demyelinating polyradiculoneuropathy.

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In chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) the pathophysiology underlying permanent muscle weakness and sensory loss was studied in 22 stabilized long-term CIDP patients clinically characterized using isokinetic dynamometry, quantitative sensory testing, and neuropathy

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