Cardiotoxicity

Osteosarcoma

Myocardial Injury

Chemotherapy Induced Systolic Dysfunction

Doxorubicin Induced Cardiomyopathy

CMR T1 mapping, T2mapping, T2* mapping, LGE, ECV

contrast-enhanced cardiac magnetic resonance imaging(MAGNETOM Aera 1.5T)

2nd Affiliated Hospital, School of Medicine, Zhejiang University

Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR

Cancer therapy-related cardiac dysfunction was defined as an LVEF reduction >10% from baseline, or LVEF <53%

Change in T1 mapping values before and after anthracyclin chemotherapy

Change in T2 mapping values before and after anthracyclin chemotherapy

Change in T2* mapping values before and after anthracyclin chemotherapy

Second Affiliated Hospital, School of Medicine, Zhejiang University

Osteomyelitis

UT Southwestern Medical Center

Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT)

Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis

Serial measurements of procalcitonin at Baseline, Week 3 and Week 6.

University of Texas Southwestern Medical Center

acupuncture will be administered after induction for a period of 30 minutes, followed by a 30 minute rest period and then resumption of acupuncture for 30 minutes.

no acupuncture will be done on this group of subjects

acupuncture will be administered after induction for a period of 30 minutes, followed by a 30 minute rest period and then resumption of acupuncture for 30 minutes.
acupuncture: One half of subjects will receive a standardized acupuncture regiment

Acupuncture

no acupuncture will be done on this group of subjects. Since they are under general anesthesia they will not realize they are acting as control group
no acupuncture: placebo

Sham/Placebo

Total

Age, Customized

Sex: Female, Male

Region of Enrollment

analgesia provided in Post Anesthesia Care Unit PACU)

no acupuncture will be done on this group of subjects. These subjects will be under general anesthesia and will not be aware that they are in control group.
no acupuncture: placebo

Reduced Pain Medication Requirement

VAS is a self reported pain scale with a score ranging from 0 to 10. 0= no pain, 10=worst pain possible. Multiple pain sacores were recorded. single value is reported by average

Visual Acuity Score (VAS)

All blood samples were collected during general anesthesia, the first prior to surgical incision and electroacupuncture, the second 60 minutes after incision time and at the completion of electroacupuncture, the third after arrival in PACU but before the administration of analgesia. The data below represents female patients only

(ACTH )Adrenocorticotropic Hormone

All analgesic treatments were converted to morphine equivalents in milligrams .

no acupuncture will be done on this group of subjects
no acupuncture: placebo

Morphine Equivalent

morphine equivalent to analyze whether body weight affected the efficacy of electroacupuncture

Morphine Equivalent (mg)

Modified patient self reported scale with 9 questions regarding general well being including ability to eat, free from constant pain, able to manage activities of daily living. 0= worst possible score and 18=best outcome score

Modified Quality of Recovery Scale

All blood samples were collected during general anesthesia, the first prior to surgical incision and electroacupuncture, the second 60 minutes after incision time and at the completion of electroacupuncture, the third after arrival in PACU but before the administration of analgesia.

Cortisol

equivalent doses of morphine for analgesic relief. All analgesic treatments were converted to morphine equivalents in milligrams.

Visual Acuity scale 0=no pain 10= worst pain possible

Pain Levels

the first two blood samples were collected during general anesthesia, the first prior to surgical incision and electroacupuncture, the second 60 minutes after incision time and at the completion of electroacupuncture, the third after arrival in PACU but before the administration of analgesia.

Glucose

First two blood samples were collected during general anesthesia, first prior to surgical incision and Electro-acupuncture (EA), 2nd 60 minutes after incision and EA, third after arrival in PACU but before administration of analgesia. TNF is a critical pyrogen produced during acute phase of a reaction to trauma.

Tumor Necrosis Factor (TNF)

both are IL-2 and IL-4 are critical cytokines regulating the cellular response to induce cellular versus hormone immunity. First two blood samples were collected during general anesthesia: first prior to surgical incision and electroacupuncture, second 60 minutes after incision and electroacupuncture and the 3rd after arrival in PACU but before analgesia.

iNTERLEUKIN (IL-2 and IL-4)

First two blood samples were collected during general anesthesia, first prior to Surgical incision and EA, 2nd 60 minutes after incision and EA and the 3rd after arrival in PACU but before administration of analgesia. IL-6 is a critical inflammatory cytokine produced during the acute phase of reaction to trauma

IL-6

IL-10 is an anti-inflammatory cytokine marker. First two blood samples were collected during general anesthesia, first prior to surgical incision and EA, 2nd 60 minutes following incision and EA, and the third after arrival in PACU but before administration of analgesia.

IL-10

TGFB1 is a pleiotropic factor regulating the immune system and healing. First two blood samples drawn under general anesthesia, first prior to surgical incision and EA, the 2nd 60 minutes after incision and EA, third after arrival in PACU but before administration of analgesia.

TGFB1

to determine if electroacupuncture reduced hyperglycemia

Serum Insulin Level

acupuncture will be administered after anesthesia induction for a period of 30 minutes, followed by a 30 minute rest period and then resumption of acupuncture for 30 minutes.
acupuncture: One half of subjects will receive a standardized acupuncture regiment

no acupuncture will be done on this group of subjects but since they will be under general anesthesia they will not be aware that they are the control group
no acupuncture: placebo

Sham

Overall Study

Dennis Grech, MD

Thyroid or Parathyroid Surgery

One half of subjects will receive a standardized acupuncture regiment

bone neoplasms/ödem

Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR

Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis (PCT)

Acupuncture for Reduction of Inflammation

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