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carboxylic acid/infarkt
Länken sparas på Urklipp
15 resultat
Process for imaging cardiac infarcts
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BACKGROUND OF THE INVENTION
Radiopharmaceuticals are widely used to evaluate cardiac function. Among the radioactive agents employed are, for example, .sup.99m Tc-labeled human serum albumin and .sup.99m Tc-labeled red blood cells for determination of cardiac blood volume, left ventrical wall
4,5-dihydro-[1H]-benz[g]indazole-3-carboxylic acid derivatives
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CROSS-REFERENCE
This application is a 371 of PCT/JP98/02758 filed Jun. 22, 1998, which is based on Japanese Application No. 199,128/97 filed Jul. 10, 1997.
TECHNICAL FIELD
This invention relates to novel 4,5-dihydro-[1H]-benz[g]-indazole-3-carboxylic acid derivatives. More particularly, it relates
Branched carboxylic acid compound and use thereof
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TECHNICAL FIELD
The present invention relates to a compound, which is useful for medicinal drug, represented by formula (I):
##STR00002## wherein all symbols have the same meanings as described below, use thereof, and a pharmaceutical composition comprising the same as an active
Vinyl carboxylic acid derivatives, their production and use as inhibitors of thromboxane synthetase
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The present invention relates to novel substituted vinylcarboxylic acid derivatives which possess the action to inhibit specifically the thromboxane A.sub.2 (TXA.sub.2) synthetase.
TXA.sub.2 is a metabolite of arachidonic acid and has the platelet aggregating action. Therefore, it has been known
7-[(4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
7[4'-trifluoromethyl-biphenyl-2-carbonyl)amino]-quinoline-3-carboxylic acid amides, and method of inhibiting the secretion of apolipoprotein B
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FIELD OF THE INVENTION
This invention relates to compounds that inhibit the secretion of apolipoprotein B, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia,
Sulfur containing trialkoxybenzoylamino carboxylic acids
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The invention is directed to compounds of the formula: ##STR2## wherein:
A is a straight or branched chain alkylene or alkylidene radical having 2 to 5 carbon atoms and which is substituted by an alkylthio group having 1 to 4 carbon atoms, a carboxymethyl thio group, a carboxyethyl thio group, an
Sulfur containing trialkoxybenzoylamino carboxylic acids
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The invention is directed to compounds of the formula: ##SPC2##
Wherein:
A is a straight or branched chain alkylene or alkylidene radical having 2 to 5 carbon atoms and which is substituted by an alkylthio group having 1 to 4 carbon atoms, a carboxymethyl thio group, a carboxyethyl thio group, an
Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals
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The present invention relates to compounds of the formula I,
##STR00002## wherein A, Y, Z, R.sup.20 to R.sup.22 and R.sup.50 have the meanings indicated below, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2
Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals
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The present invention relates to compounds of the formula I,
##STR00002## wherein A, Y, Z, R.sup.20 to R.sup.22 and R.sup.50 have the meanings indicated below, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2
Carboxylic acid derivatives and drugs containing the same as the active ingredient
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TECHNICAL FIELD
The present invention relates to carboxylic acid derivatives and pharmaceutical compositions comprising the same as an active ingredient. More specifically, the present invention relates to (1) carboxylic acid derivatives represented by formula (I)
##STR00002## prodrugs thereof,
Substituted-phthalazone 7-carboxylic acid and salts and process for preparing same
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to novel phthalazone derivatives and more particularly to compounds of the formula ##STR2## wherein R.sup.4 represents a carbamoyl (--CONH.sub.2) group, a dialkylaminoalkylcarbamoyl group, a hydroxyalkylcarbamoyl
S-nitroso derivatives of hydrazinoacetic acids, 1-[(acylthio and (mercapto)-1-oxoalkyl]-1,2,34-Tetrahydroquinoline-2-carboxylic acids and alanyl prolines and isoquinolines
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FIELD OF THE INVENTION
This invention relates to new pharmaceutical preparations and the use thereof for the treatment of various pathophysiological diseases including acute myocardial infarction, left ventricular dysfunction without overt heart failure, congestive heart failure, angina pectoris,
(4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamides
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BACKGROUND OF THE INVENTION
The present invention relates to (4-arylsulfonylamino)-tetrahydropyran-4-carboxylic acid hydroxamide derivatives, and to pharmaceutical compositions and methods of treatment.
The compounds of the present invention are inhibitors of zinc metalloendopeptidases, especially
Inhibitor of ischemic disorders
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RELATED APPLICATIONS
This application claims the priority of Japanese Patent Application No. 2007-225021 filed on Aug. 31, 2007, which is incorporated herein by reference.
FIELD OF THE INVENTION
The present invention relates to the pharmaceuticals useful for the treatment and prevention of the
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