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carboxylic acid/kräkning
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Sida 1 från 26 resultat
Indazolyl carboxylic acid amides useful for treating migraine clusters headache, trigeminal neuralgia or emesis
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This invention relates to novel compounds having useful pharmacological properties, to pharmaceutical compositions containing them, to a process and intermediates for their preparation, and to their use as pharmaceuticals.
UK Patent Applications, GB Nos. 2100259A and 2125398A describe benzoates and
Derivatives of 4,5,6,7-tetrahydroimidazo-[4,5-c]pyridinyl-6-carboxylic acid
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FIELD OF THE INVENTION
This invention relates to derivatives of novel 4,5,6,7-tetrahydroimidazo[4,5-c]pyridinyl-6-carboxylic acid useful as potent and selective anti-emetic or anti-nausea agents, or both, for pre-operative, intra-operative, and post-operative use.
BACKGROUND OF THE INVENTION
Nausea
Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds
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BACKGROUND OF THE INVENTION
This invention is concerned with compounds of structural formula I: ##STR1## wherein X is --CH.dbd.CH--, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --O--, --O--CH.sub.2 --, --S--CH.sub.2 --, --CH.sub.2 --S--, --S-- or --O--, and R is a 5- or 6-membered nitrogen heterocyclic
Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds
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BACKGROUND OF THE INVENTION
This invention is concerned with compounds of structural formula I: ##STR1## wherein X is --CH.dbd.CH--, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --O--, --O--CH.sub.2 --, --S--CH.sub.2 --, --CH.sub.2 --S--, --S-- or --O--, and R is a 5- or 6-membered nitrogen heterocyclic
Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
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BACKGROUND OF THE INVENTION
1. Field of Invention
Novel 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.2.1]octanes and 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.3.1]nonanes are coupled with aryl carboxylic acids to obtain the corresponding amides and esters. These novel amides and esters,
Carbocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents
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BACKGROUND OF THE INVENTION
1. Field of Invention
Novel 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.2.1]octanes and 5-aminomethyl-and 5 -hydroxymethyl-1-azabicyclo[3.3.1]nonanes are coupled with aryl carboxylic acids to obtain the corresponding amides and esters. These novel amides and esters,
5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT.sub.3 antagonists
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BACKGROUND OF THE INVENTION
A variety of agents are presently under development as potential treatments for migraine headaches. For example, MDL-72222 (tropine 3,5-dichlorobenzoate) is reported to block the M-receptors for 5-hydroxytryptamine (5-HT), now referred to as 5-HT.sub.3 receptors, thereby
Certain 2,3-dihydro-2;2-dimethyl-benzothiophene carboxylic acids which are intermediates
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BACKGROUND OF THE INVENTION
A variety of agents are presently under development as potential treatments for migraine headaches. For example, MDL-72222 (tropine 3,5-dichlorobenzoate) is reported to block the M-receptors for 5-hydroxytryptamine (5-HT), now referred to as 5-HT.sub.3 receptors, thereby
Benzimidazolone carboxylic acid derivatives
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BACKGROUND OF THE INVENTION
This invention relates to benzimidazolone carboxylic acid derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives
Benzimidazolone carboxylic acid derivatives
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BACKGROUND OF THE INVENTION
This invention relates to benzimidazolone carboxylic acid derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives
Benzimidazolone carboxylic acid derivatives
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BACKGROUND OF THE INVENTION
This invention relates to benzimidazolone carboxylic acid derivatives. These compounds have selective 5-HT.sub.4 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives
Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
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BACKGROUND OF THE INVENTION
The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt
Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
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BACKGROUND OF THE INVENTION
The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt
Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
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BACKGROUND OF THE INVENTION
The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt
Meso-azacyclic amides of certain bicyclic carboxylic acids
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BACKGROUND OF THE INVENTION
The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt
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