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Leptin Infusion and Endothelial Vasomotor Response

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Introduction High BMI and particularly fat mass index are associated with increased risk of coronary artery disease and other cardiovascular conditions, but the underlying mechanisms are not well understood. Endothelial dysfunction precedes atherosclerosis and represents an important link between

LOD vs Gn in Anovulatory PCOs Resistant to First Line Agents

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PCOS is a complex disease that is diagnosed by the presence of two of the following three: oligo/anovulation, clinical and/or biochemical hyperandrogenism, or polycystic ovaries by ultrasound . PCOS affects 4% to 21% of females in reproductive age . Although subfertility is abundant in women with

Glucose Metabolism in Brown Adipose Tissue (BAT) in Young Healthy Men Evaluated by Deuterium Metabolic Imaging (DMI)

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The prevalence of obesity and type 2 diabetes has increased exponentially over the past decades giving rise to substantial individual as well as health economic costs. Therefore, more research are warranted in the development of new prevention and treatment strategies. In 2009 findings using

Vitamin D for Polycystic Ovary Syndrome Clomiphene Resistant Women

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Polycystic ovary syndrome (PCOS) is considered one of the most common endocrine disorders affecting women in their reproductive age. Genetically it is thought to be involving defects in primary cellular control mechanisms resulting in expression of chronic anovulation and androgen excess. Being

Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH

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AIM 1: To determine whether MS is associated with intramuscular lipid accumulation and impaired skeletal muscle metabolism and perfusion in human PAH. Rationale: MS and IR are highly prevalent amongst PAH patients even in the absence of obesity and diabetes. There are several lines of evidence in

Comparison of Probiotics, Metformin & Their Combination Therapy in the Treatment of PCOS

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Polycystic ovary syndrome (PCOS) is a hormonal disorder affecting the women of reproductive age. It is a heterogeneous health condition that affects 1 in every 10 women of childbearing age. Women of all races and ethnicities are at risk for PCOS, but risk increases multiple folds if the BMI is

Microvesicles and Monocytes to Predict Mortality of Patients With Cirrhosis

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Natural history of cirrhosis Cirrhosis is the end stage form of chronic liver disease. It is estimated that 200,000 to 500,000 people in France have cirrhosis. Cirrhosis is responsible for more than 170,000 deaths per year in Europe. The main causes of cirrhosis include excessive alcohol

Magnesium and Vascular Stiffness

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Observational epidemiologic studies have observed an inverse relationship between daily dietary magnesium intake and blood pressure. Except for blood pressure, magnesium may also beneficially affect other cardiovascular risk markers. Whether all these effects translate into improved vascular

Effect of Time-Restricted Feeding on Fat Loss and Cardiometabolic Risk Factors in Overweight Adults

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Study of the Crystallization Inhibition Capacity of the Uric Acid in Urine in a Group of Lithiasic Patients After Intake of a Food Supplement

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Background Urolithiasis is a pathology known since antiquity although they are not known totally the causes of the formation of all the different types of calculus existing As a consequence of this, only in some cases has it been possible to develop an efficient treatment. Renal lithiasis affects a

Effect of Vitamin D Supplement in Induction of Ovulation in Overweight Women With Polycystic Ovary Syndrome

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The study will include overweight infertile women with PCOS seeking fertility who will receive induction of ovulation by clomiphene citrate will be recruited and randomized into two groups: Group A (study group): 93 women who will receive clomiphene citrate for induction of ovulation with vitamin D

Genetic Polymorphism Contributing to the Variability of Clopidogrel Response in Patients With Coronary Artery Disease

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In an observational study with cross-sectional analysis and prospective data collection, the investigators recruit patients with: - >20 years old - An established coronary artery disease defined by an episode of ST‐elevation myocardial infarction, non‐ST‐elevation acute coronary syndrome or stable

The Relation Between Adiposity, Inflammation, Glycaemia and Iron Absorption

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1. Obese subjects with central and peripheral obesity During the first phase, overweight/obese subjects with a BMI 28-35 Kg/m2 will be invited to a screening. At the screening, anthropometrics (weight, height, waist circumference) and body composition (using BIA and DEXA) will be measured. Based on

Calcium, Protein and Gut Hormones

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Participants will be asked to arrive to the laboratory between 08:00 and 10:00 am after not eating for between 8-14 hours i.e. in a fasted state (water intake is permitted and encouraged). Participants will then be given one of three test drinks: 1) calcium citrate (1000 mg); 2) milk mineral

Mitochondrial Energy Metabolism in Obese Women

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Specific objectives: Body composition by deuterium oxide; Metabolic rate of resting and oxidation of substrates by indirect calorimetry; Proinflammatory cytokines Anti-inflammatory cytokines Oxidative Stress: Malondialdehyde, Superoxide Dismutase, Glutathione-Peroxidase; Fatty acids: ceramide and

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