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colchicine/neoplasms
Länken sparas på Urklipp
Sida 1 från 16 resultat
Inhibition of wound contraction with paclitaxel, colchicine and penicillamine
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a method and composition for controlling scar formation and more particularly to the use of Paclitaxel and/or Colchicine and/or penicillamine for the inhibition of wound contraction and scar overgrowth while enhancing
Colchicine-skeleton compounds, their use as medicaments and compositions containing them
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TECHNOLOGICAL BACKGROUND
The present invention relates to novel colchicine derivatives having antiproliferative, antineoplastic and antiinflammatory activities, the methods for the preparation thereof and the pharmaceutical formulations containing them.
Colchicine is a known pseudo-alkaloid widely
Colchicine derivatives, methods and uses thereof
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FIELD OF THE INVENTION
The present invention relates generally to colchicine derivatives, methods and uses thereof.
BACKGROUND OF THE INVENTION
Any references cited herein are incorporated by reference.
Targeted molecular medicine is an exciting research approach, aimed at developing safer and more
Taxane derivatives having a pyridyl substituted C13 side chain, their preparation and their use as anti-tumor agents
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The invention relates to pharmacologically active compounds that have the ability to influence the polymerisation and depolymerisation of tubulin.
A range of natural mitosis toxins are used as anti-tumour agents or are in the process of being clinically tested. There are various classes of such
Compounds for treatment of cancer
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FIELD OF THE INVENTION
The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.
BACKGROUND OF THE INVENTION
Cancer is the second most common cause of death in the United
Compounds for treatment of cancer
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FIELD OF THE INVENTION
The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.
BACKGROUND OF THE INVENTION
Cancer is the second most common cause of death in the United
Colchicine derivatives
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INTRODUCTION
1. Field of the Invention
This invention relates to novel colchicine derivatives that are useful for treating various types of cancer.
2. Background of the Invention
Colchicine is a known compound having the following formula ##STR1##
The rings are referred to as A (the phenyl ring
Halocombstatins and methods of synthesis thereof
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FIELD OF THE INVENTION
This invention relates to novel compounds having utility in the treatment of cancer and/or as antimicrobials.
BACKGROUND OF THE INVENTION
Pharmaceutical agents to treat cancer and/or tumors are widely sought. Antiangiogenesis agents are being pursued as a promising antitumor
Halocombstatins and methods of synthesis thereof
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FIELD OF THE INVENTION
This invention relates to novel compounds having utility in the treatment of cancer and/or as antimicrobials.
BACKGROUND OF THE INVENTION
Pharmaceutical agents to treat cancer and/or tumors are widely sought. Antiangiogenesis agents are being pursued as a promising antitumor
Tubulin inhibitors and methods of using the same
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BACKGROUND OF INVENTION
1. Field of the Invention
The invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds having anti-mitotic activity, and the use of these compounds for treating diseases associated
Mammalian DNA topoisomerase II inhibitor and method
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FIELD OF THE INVENTION
The present invention relates to a colchicine derivative effective to inhibit cell growth in tumor cells.
REFERENCES
Baum, R, et al., (1989) Chem. Eng. News, June 26, p. 7.
Bishop, J. E., et al., (1991) J. Med. Chem. 34:1612.
Boer, T. J. D., et al., Org. Syn. Coll.
Mammalian DNA topoisomerase II inhibitor and method
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FIELD OF THE INVENTION
The present invention relates to a colchicine derivative effective to inhibit cell growth in tumor cells.
References
Baum, R, et al., (1989) Chem. Eng. News, June 26, p. 7.
Bishop, J. E., et al., (1991) J. Med. Chem. 34:1612.
Boer, T. J. D., et al., Org. Syn. Coll.
Tricyclic derivatives and their use
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FIELD OF THE INVENTION
The present invention relates to novel tricyclic colchicine derivatives represented by the formulas (I) or (II), or pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an
Allocolchinones and uses thereof
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BACKGROUND OF THE INVENTION
Colchicine (1) is an alkaloid having a tricyclic ring structure. A numbering system for the ring atoms and a lettering system for the three rings are indicated in (1). ##STR1##
Colchicine binds to the protein tubulin irreversibly. Tubulin is part of the cellular
Pharmaceutical and dietary composition
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FIELD OF THE INVENTION
This invention relates to the treatment of certain diseases and disorders primarily, but not exclusively, in the field of human medicine and to compositions for use therein.
GENERAL BACKGROUND
Considerable interest has been shown in recent years in the use of prostaglandin
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