The proposed study will include 15 UC anti-TNF naïve patients . We will consider remission when patients have an endoscopic Mayo score ≤1, and activity index score, Mayo= 0 points.
Stool samples will be collected before starting Anti-TNF treatment (M0), and then every 3 months (M1, M2, M3 and M4) to complete the study.
GOLIMUMAB induction with 200mg at week 0, and 100mg at week 2. Under 70kg, the follow up treatment will be 50mg/month, and 100mg/month in patients over 70kg, as clinical practice.

Ulcerative Colitis

Golimumab

Hospital Doctor Josep Trueta

Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis

Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis: Pilot Study

Previous to the treatment with golimumab( week 0) and every month thereafter up to week 28

Previous to the treatment with golimumab (week 0) and every month thereafter up to week 28.

Previous to the treatment with golimumab ( week 0) and every month thereafter up to week 28.

Xavier Aldeguer

Head of Gastroenterology Department

Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta

Pregnant Women in All Gestational Ages Hospitalized for a Problem of Pregnancy.

Some of these questionnaires will have to be completed every day and others every other day:
The Internet questionnaire is divided in two parts. The first one investigates the use of internet at home and it will be administered only once, the second part will investigate the internet use at the hospital, in the case the women have a personal smartphone, tablet or personal computer (they are the owners) and it will be administered every other days.
The questionnaire is aimed to understand the quality of life (EQ-5D) will be administered only once, at the beginning of the hospitalization.
The STAI questionnaire is divided in to parts, the first part aims to determinate the state anxiety and it will be administered every other day, while the second part will discuss the anxiety itself, and has to completed only once.
The short questionnaire on critical events occurring during the day,
The short questionnaire with obstetric anamnesis.

At the first day of hospitalization the field investigator will submit to pregnant women in a pathological condition five questionnaires

How Anxiety in Pregnant Hospitalized Women Change wIth Internet Use

During the first day of hospitalization, the field investigator administers to every patient participating to the study all five questionnaires and on each questionnaire, it will be indicated the day when it has been completed.
The study measures the level of state anxiety in hospitalized women with pathological pregnancy, influenced by internet use. The STAI questionnaire that evaluate the level of anxiety, is divided in to parts: the first part aims to determinate the state anxiety and it will be administered every other day, while the second part will discuss the anxiety itself, and has to completed only once.

Dario Gregori

Professor

University of Padova

Azienda Ospedaliero Universitaria, Santa Maria della Misericordia di Udine, Italy

Azienda Per I Servizi Sanitari N. 6 Friuli Occidentale

Intervention:Smokefreemoms texting and quitline referral

Intervention:Smokefreemoms texting and Brief intervention

Intervention: Quitline referral and Brief intervention

Intervention:Smokefreemoms texting, Quitline referral and Brief intervention

Tobacco Use Cessation

SmokeFreeMom is a mobile text messaging service designed for pregnant women across the United States to help them quit smoking. The program provides 24/7 encouragement, advice, and tips to help pregnant women and mothers quit smoking and stay quit.
The 1-800 QuitLine provides smoking cessation services to Michigan residents who want to quit using tobacco. The Quit Line offers a personal health coach and participant toolkits to help tobacco users gain confidence and motivation they need to quit for good.
Computer-delivered 5As (CD-5As) brief intervention The software platform to be used for this study features an interactive three-dimensional narrator, clear and relevant graphics, and aura;Participants use headphones for privacy while working with the computer.

Referral to SmokeFreeMoms, Quitline or Brief intervention

Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study.

To compare the effects on smoking of an online brief intervention to those of referral to a free online text messaging intervention, and to those of free phone counseling through the Michigan Quitline.

Elena Bronshtein

MFM Fellow

Wayne State University

Methadone (1 mg/mL) administered orally every 4 hours. The following is a dosing guide:
NAS Score Methadone 8-12 0.05 mg/kg/dose >=13 0.1 mg/kg/dose
Maximum dose of methadone will be 0.2 mg/kg/dose. (NeoFax)
Additional doses, 0.05 mg/kg, may be given every 4 hours as needed and added to the next 24 hour's doses divided every 4 hours, until NAS scores are consistently <8 for 48 hours.
If the maximum dose of methadone is reached and if withdrawal is not controlled, the infant will be started on clonazepam (0.005 mg/kg/dose q 12h) per current treatment.

Morphine (1 mg/mL) administered orally every 4 hours. The following is a dosing guide:
NAS Score Morphine 8-12 0.05 mg/kg/dose >=13 0.1 mg/kg/dose
Maximum dose of morphine will be 0.2 mg/kg/dose. (NeoFax)
Additional doses, 0.05 mg/kg, may be given every 4 hours as needed and added to the next 24 hour's doses divided every 6 hours, until NAS scores are consistently <8 for 48 hours.
If the maximum dose of morphine is reached and if withdrawal is not controlled, the infant will be started on clonazepam (0.005 mg/kg/dose q 12h) per current treatment.

infants randomized to receive morphine as their primary treatment for withdrawal

Morphine Treated

infants randomized to receive methadone as their primary treatment for withdrawal

Methadone Treated

Total

Sex: Female, Male

The length of time in days that the treatment opioid was used on a measured taper to ameliorate withdrawal signs

group of infants randomized to receive methadone treatment for their withdrawal

Methadone-treated

Group randomized to receive morphine treatment for their withdrawal

Morphine-treated

Days of Treatment With Opioid Medication

Number of infants treated with a second drug to treat their withdrawal

Second Drug for Withdrawal

Methadone (1 mg/mL) administered orally every 4 hours. The following is a dosing guide:
NAS Score Methadone 8-12 0.05 mg/kg/dose >=13 0.1 mg/kg/dose
Maximum dose of methadone will be 0.2 mg/kg/dose. (NeoFax)
Additional doses, 0.05 mg/kg, may be given every 4 hours as needed and added to the next 24 hour's doses divided every 4 hours, until NAS scores are consistently <8 for 48 hours.
If the maximum dose of methadone is reached and if withdrawal is not controlled, the infant will be started on clonazepam (0.005 mg/kg/dose q 12h) per current treatment.
Methadone, Morphine: To compare the duration of opiate medication treatment for babies on methadone versus those on morphine.

Methadone

Morphine (1 mg/mL) administered orally every 4 hours. The following is a dosing guide:
NAS Score Morphine 8-12 0.05 mg/kg/dose >=13 0.1 mg/kg/dose
Maximum dose of morphine will be 0.2 mg/kg/dose. (NeoFax)
Additional doses, 0.05 mg/kg, may be given every 4 hours as needed and added to the next 24 hour's doses divided every 6 hours, until NAS scores are consistently <8 for 48 hours.
If the maximum dose of morphine is reached and if withdrawal is not controlled, the infant will be started on clonazepam (0.005 mg/kg/dose q 12h) per current treatment.
Methadone, Morphine: To compare the duration of opiate medication treatment for babies on methadone versus those on morphine.

Morphine

Overall Study

Dr. Mark Brown

Neonatal Abstinence Syndrome

To compare the duration of opiate medication treatment for babies on methadone versus those on morphine.

colic/nikotin

Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis

How Anxiety in Pregnant Hospitalized Women Change wIth Internet Use

Optimizing Technology-Delivered Interventions for Smoking in Pregnancy: The Mommy Check-Up Study.

Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal

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