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cyanogenic glycoside/neoplasms
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Laetrile treatment for cancer.
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BACKGROUND
Laetrile is the name for a semi-synthetic compound which is chemically related to amygdalin, a cyanogenic glycoside from the kernels of apricots and various other species of the genus Prunus. Laetrile and amygdalin are promoted under various names for the treatment of cancer although
In vitro cytotoxicity following specific activation of amygdalin by beta-glucosidase conjugated to a bladder cancer-associated monoclonal antibody.
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We describe a novel version of antibody-directed enzyme prodrug therapy (ADEPT), with the use of amygdalin as prodrug. Amygdalin is a naturally occurring cyanogenic glycoside, which can be cleaved by sweet almond beta-glucosidase to yield free cyanide. If amygdalin could be activated specifically at
[Alternative means of drug therapy in cancer: letril].
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Letril (amygdaline) is one of drugs of alternative therapy for cancer that is used over three decades and relates to cyanogenic glycosides received from kernels of various fruits (almonds, apricots, peaches, etc. The basis of suggestion of letril as antitumor agent is hypotheses about selective
Anti-tumor promoting effect of glycosides from Prunus persica seeds.
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Four minor components, along with the major cyanogenic glycosides, amygdalin and prunasin, were isolated from Prunus persica seeds (Persicae Semen; Tounin), and characterized as mandelic acid glycosides (beta-gentiobioside and beta-D-glucoside) and benzyl alcohol glycosides (beta-gentiobioside and
The case against laetrile: the fraudulent cancer remedy.
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The evidence for the claims that laetrile (amygdalin) can prevent or control cancers has been reviewed. The beta-glucosidase content of cancer tissues is low compared to that of normal liver and small intestine. Cancer tissues contain the enzyme rhodanese in amounts comparable to that of liver and
Laetrile treatment for cancer.
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BACKGROUND
Laetrile is the name for a semi-synthetic compound which is chemically related to amygdalin, a cyanogenic glycoside from the kernels of apricots and various other species of the genus Prunus. Laetrile and amygdalin are promoted under various names for the treatment of cancer although
Amygdalin, from Apricot Kernels, Induces Apoptosis and Causes Cell Cycle Arrest in Cancer Cells: An Updated Review.
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Amygdalin is a cyanogenic glycoside which is described as a naturally occurring anti-cancer agent. In 1830s, French chemists Robiquet and Boutron-Charlard isolated amygdalin from bitter almonds. Apoptosis is an important mechanism in cancer treatment by amygdalin. Amygdalin can probably stimulate
UPLC-Q-TOF-MS Study of the Mechanism of THSWD for Breast Cancer Treatment.
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Taohong Siwu decoction (THSWD) is a classic traditional Chinese medicine (TCM) prescription that is widely used in the clinical treatment of gynecological and cerebrovascular diseases. Here we used a method that coupled ultra-performance liquid chromatography to quadrupole time-of-flight mass
The anti-cancer effect of amygdalin on human cancer cell lines.
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Derived from rosaceous plant seed, amygdalin belongs to aromatic cyanogenic glycoside group, and its anticancer effects have been supported by mounting evidence. In this study, we objected to investigate amygdalin effect on two antiapoptotic genes (Survivin, XIAP) and two lncRNAs (GAS5, MALAT1) in
Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells.
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Amygdalin, D-mandelonitrile-β-D-glucoside-6-β-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor agent against breast cancer cells
Problems and Pitfalls in the Analysis of Amygdalin and Its Epimer.
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α-[(6-O-β-d-Glucopyranosyl-β-d-glucopyranosyl)oxy]-(αR)-benzeneacetonitrile, or R-amygdalin, is the most common cyanogenic glycoside found in seeds and kernels of the Rosaceae family and other plant genera such as Passiflora. Many commercially important seeds are analyzed for amygdalin content. In
Effects of cyanogenic agents on reproduction and neonatal development in rats.
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A diet consisting of 50% gari (a form of cassava meal) was found to cause no significant biochemical and haematological changes in adult female rats. Although this diet caused a significant increase in their serum thiocyanate levels, there was no corresponding significant increase in the weight of
Tropical calcific pancreatitis.
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Tropical calcific pancreatitis is a special type of chronic pancreatitis that has features quite different from those of alcoholic pancreatitis and is seen almost exclusively in tropical countries. It is characterized by recurrent severe pain in the abdomen, insulin-requiring but ketosis-resistant
Acute Cycas seed poisoning in Taiwan.
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OBJECTIVE
The seeds of cycads contain cycasin and neocycasin, which belong to the family of cyanogenic glycosides. These glycosides of cycads are considered pseudocyanogenic with little potential to liberate hydrogen cyanide as other cyanogenic glycosides do. This study investigated the clinical
Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay
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Amygdalin is a cyanogenic glycoside, mainly present in the seeds of the Rosaceae family such as apricots, peaches, and bitter almond. In this study, in vitro genotoxic and antigenotoxic effects of amygdalin have been investigated on human peripheral blood lymphocytes using the comet assay. The
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