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Clinical predictors of bioterrorism-related inhalational anthrax.

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Limitation of a bioterrorist anthrax attack will require rapid and accurate recognition of the earliest victims. To identify clinical characteristics of inhalational anthrax, we compared 47 historical cases (including 11 cases of bioterrorism-related anthrax) with 376 controls with

Topical benzocaine (Hurricaine) induced methemoglobinemia during endoscopic procedures in gastric bypass patients.

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BACKGROUND Methemoglobinemia results from oxidation of ferrous to ferric iron in hemoglobin. In addition to a functional anemia, methhemoglobinemia causes the O2-binding affinity of the remaining O2 sites in the hemoglobin tetramer to increase; essentially shifting the oxyhemoglobin dissociation

Evaluation of the safety and tolerability of a short higher-dose primaquine regimen for presumptive anti-relapse therapy in healthy subjects.

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The safety and tolerability of primaquine (PQ) administered as a short higher-dose (30mg twice daily for 7 days) regimen in 203 Australian Defence Force personnel was evaluated in an open-label presumptive anti-relapse therapy study. No clinically significant differences were measured in the

Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study.

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BACKGROUND Spotted Fever Rickettsiosis (SFR), an acute febrile illness caused by Rickettsia rickettsii, R. conorii and R. akari which is associated with considerable morbidity and mortality. SFR is one of the most covert emerging infections of the present time which is prevalent in various parts of

Hypermagnesemia following aluminum phosphide poisoning.

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Aluminum phosphide (ALP) is highly toxic to the lungs, heart and blood vessels causing pulmonary edema, shock and arrhythmias. There is massive focal myocardial damage resulting in raised cardiac enzymes. This study included 92 patients of proven ALP poisoning. The age varied between 20-50 years and

Drug-induced methaemoglobinaemia. Treatment issues.

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In normal erythrocytes, small quantities of methaemoglobin are formed constantly and are continuously reduced, almost entirely by the reduced nicotine adenine dinucleotide (NADH) diaphorase system, rather than the reduced nicotine adenine dinucleotide phosphate (NADPH) diaphorase system.

Headache and Methemoglobinemia.

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This basic review is intended to summarize the current knowledge of methemoglobinemia as an important cause of secondary headache with the hope of generating a growing interest in studying this phenomenon.We describe the pathological underpinnings of

[Ergotamine poisoning: a case study].

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Ergotamine is a well known pharmacological remedy applied in neurology (treatment of vascular headache) and in obstetrics (abortive remedy, uterus atony). But today it is rarely used, because of new safer anti-migraine medicine (triptanes) which cause fewer side effects. According to obstetrical

Delayed sulfhemoglobinemia after acute dapsone intoxication.

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A case of acute Dapsone intoxication due to voluntary ingestion of 3 g of this drug as a suicide attempt is described. A severe methemoglobinemia developed, accompanied by intense cyanosis, dyspnea, headache, and nausea. Subsequently, significant sulfhemoglobinemia responsible for prolonged cyanosis

[Acute respiratory failure after metoclopramide for methemoglobinemia - a rare and potentially life-threatening side effect].

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METHODS A 85-year-old patient, initially treated for aspiration pneumonia on the intensive care unit acutely complained again of nausea which was immediately treated by an i. v. bolus of metoclopramide (MCP). Without another incident of aspiration she subsequently developed acutely massive dyspnoea,

[Acute cardiogenic shock with inferior myocardial infarction associated with an abnormal origin of the coronary arteries].

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METHODS A 45-year-old previously healthy man was admitted as an emergency having suddenly gone into cardiogenic shock. He had not been on any medications. The only known risk factor for cardiovascular disease was heavy smoking. METHODS The patient was awake and responsive on admission but showed

Association between acute severe mercury poisoning and multiple organ failure

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Acute mercury poisoning, involving a number of organs, leads to severe dysfunctions, such as acute renal failure (ARF), and even threatens patients' lives. A case of acute severe mercuric chloride (HgCl₂) poisoning with multiple organ failure was reported in this study. A 38-year-old

Multi-center retrospective evaluation of oral benzocaine exposure in children.

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On rare occasions benzocaine has produced methemoglobinemia from oral, rectal and dermal exposures. There is disagreement whether this is an idiosyncratic event or a dose-related event. To gain a better perspective on this problem we retrospectively reviewed cases at 4 large regional poison centers

Can aluminium phosphide poisoning cause hypermagnesaemia? A study of 121 patients.

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Aluminium phosphide (ALP) poisoning is one of the major causes of death in northern India. It is the commonest mode for suicide. The present study includes 121 patients of proven ALP poisoning. The age varied between 20 and 45 years, and the majority (95) were females. Clinical manifestations were

[Material and mechanisms induced pseudo allergic reactions of Yuxingcao injection].

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OBJECTIVE To investigate the characteristics, sensitizin and the mechanism of pseudo allergic reaction induced by Yuxingcao injection. METHODS Beagle dogs were randomly assigned to control group, 0.5% tween 80 group, Yuxingcao injection without tween 80 group, Yuxingcao injection included 0.5% tween

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