Blood samples from which platelet function and platelet mitochondrial function will be analyzed, as well as serum markers for mitochondrial function

Platelet Dysfunction

Traumatic Brain Injury

These diagnostic tests will be acquired in patients with brain injury, to determine prediction of clinical, functional and psychological outcome.

Platelet mapping Thromboelastography

Carolinas Medical Center

Correcting Platelet Dysfunction After Traumatic Brain Injury

Correction of Platelet Dysfunction Following Traumatic Brain Injury in Geriatric Patients

Correction of platelet inhibition measured before and after transfusion through platelet mapping thromboelastography

Mortality will be compared to admission platelet inhibition

Patient function as measured by Functional Independence Measure compared to platelet inhibition

Only collaborators will have patient names for data acquisition.

Susan L. Evans, MD

Principal Investigator

Atrium Health

Blood drawn within 15 minutes of arrival to the Emergency Department and at 24, 48, and 74 hours. Each sample will be processed and stored for subsequent analysis of cytochrome c and other markers of mitochondrial injury that may become available at a later time.

Trauma

Blunt Injury

Blunt Trauma

Accident

Multiorgan Injury

Advocate Lutheran General Hospital

Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome

Relationship between plasma levels of cytochrome c and the initial severity of traumatic injury as assessed by the TRISS and the severity of initial presentation based on transfusion requirements and (if available) by blood gas and chemistry analysis along with lactic acid.

Relationship between plasma levels of cytochrome c and subsequent development of organ dysfunction assessed by daily measurements of MODS and SOFA and various clinical outcomes including length of stay in ICU and in the hospital, survival to hospital discharge, and functional status upon discharge.

Contribution of individual organs injured to plasma cytochrome c levels (e.g., liver injury is likely to produce greater mitochondrial injury that thoracic injury given the greater mitochondrial density in liver tissue).

cytochrome c/blödning

Correcting Platelet Dysfunction After Traumatic Brain Injury

Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome

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