drug eruptions/ödem

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Acute exanthematous pustular drug eruption induced by mexiletine.

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A 56-year-old man developed infiltrated erythemas on the trunk, extremities, and face with marked facial edema, one month after taking mexiletine hydrochloride for his arrhythmia. A number of pustules were also noted on the surface of erythemas on his chest and face. Laboratory examination showed

Generalized pustular drug eruptions: confirmation by in vitro tests.

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BACKGROUND Generalized pustular eruptions are characterized by acute onset of aseptic pustules in febrile patients with leukocytosis after exposure to the offending drug. They have been regarded as uncommon manifestations of adverse drug reactions. Until now few confirmation studies have been

[A case of eperisone hydrochloride (myonal)--induced drug eruption leading to erythema and angioedema].

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Here we report a case of eperisone hydrochloride-induced drug eruption. A twenty-three-year-old female suffering from the common cold, headache and arthralgia was administered eperisone hydrochloride with several drugs including loxoprofen sodium. Two hours after receiving the medications, she

Histological phases of Bactrim-induced fixed drug eruption. The report of one case.

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A case is described of a patient with Bactrim-induced fixed drug eruption (FDE). Histological studies were performed at 1 day and 5 days after the drug exposure. While the 5-day-old lesion showed changes classically recognized as FDE, the 1-day-old lesion showed changes typical of a hypersensitivity

Histopathologic features of exanthematous drug eruptions of the macular and papular type.

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Although exanthematous drug eruptions of the macular and papular type are common and often cause diagnostic problems, histopathologic features are not precisely defined in the literature. We present the first prospective histopathologic study of maculopapular drug eruption in 48 patients in whom the

Fixed drug eruption due to allopurinol: positive oral provocation.

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A fixed drug eruption (FDE) is characterized by the presence of a solitary or multiple, pruritic, well-circumscribed, erythematous plaques. These lesions have tendency to recur at same sites and heal with residual hyperpigmenation. With repeated attacks, the size and/or number of the lesions may

Fixed drug eruption in Bangladeshi population: confirmed by provocative test.

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BACKGROUND Fixed drug eruption is designated as a typical allergic reaction occurring due to exposure to a medicine. This common dermatological condition is often being ignored for its causative agent as well as the patient's sufferings sometimes become unpredictable. OBJECTIVE The objective of this

Fixed drug eruptions caused by medications: a report from India.

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Fifty-five patients with fixed drug eruption were investigated to determine the drug(s) causing the reaction. History, classic clinical features of well circumscribed erythema, edema and violaceous pigmentation, and the recurrence of the eruptions on the same sites on readministering drug were used

Imatinib mesylate-induced lichenoid drug eruption.

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Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists

[Clinical analysis of 410 cases of drug eruption].

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An clinical analysis was conducted among a cohort of 410 patients drug eruption with treated in our department from January 1995 to December 2001. We found that the common drugs likely to lead to anaphylactic reactions included cephalosporins, ampicillin types, antipyretic analgesic types, rabies

Trimethoprim-Sulfamethoxazole-Induced Drug Eruption With Eosinophilia and Systemic Symptoms (DRESS).

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Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe and potentially life threatening adverse drug reaction. To help identify DRESS, several criteria have been established; however, there is still a lack of consensus on diagnosis, and clinical judgment is paramount. Here we describe

Erythema multiforme-like drug eruption with oral involvement after intake of leflunomide.

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Leflunomide is an antirheumatic agent of the type of a 'disease-modifying antirheumatic drug'. In rare cases, severe skin reactions up to the extreme expression of toxic epidermal necrolysis have been observed. A female patient with rheumatoid arthritis had been treated with systemic steroids and

Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate.

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Cutaneous reactions to imatinib are common and occur in 9.5% to 69% of patients depending on the series reported. Maculopapular eruptions, erythematous eruptions, edema, and periorbital edema are the most common adverse events observed. Imatinib can also induce severe skin eruptions and generalized

Approach to the hospitalized patient with targetoid lesions.

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Approaching the hospitalized patient with skin disease can be daunting. This article focuses on a practical approach to the patient with targetoid lesions. The discussion focuses on differentiating erythema multiforme from Stevens-Johnson syndrome and toxic epidermal necrolysis. In addition, the

Pathology of an ulcerative dermatitis in Belgian Landrace sows.

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Chronic ulcers of the skin were observed in three Belgian Landrace sows. Lesions were located on ears, limbs, and in the mammary region and were resistant to treatment that included corticosteroid therapy. Major histologic changes were located at the dermo-epidermal junction. Ulcers were deep, and

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