Current Standard of Care for inpatient colonoscopy: The dose of PEG-ELS will be large-volume (4-Liter) administered as either single-dose if colonoscopy is scheduled BEFORE 11 a.m. (250 mL orally every 15 minutes between 6 p.m. and midnight the day prior to procedure), or split-dose if the colonoscopy is scheduled AT or AFTER 11 a.m. (First dose: 2-Liters; 250 mL orally every 15 minutes between 6-8 p.m. the day prior to procedure. Second dose: 2-Liters; 250 mL orally every 15 minutes to be completed 5 hours before the scheduled time of the procedure).

The study entails giving two doses of Lubiprostone in addition to the standard large-volume polythene glycol-electrolytes solution (PEG-ELS) according to the time of the procedure as follow: If the colonoscopy is scheduled BEFORE 11a.m. the patient will receive in addition to the PEG-ELS: Lubiprostone 24 mcg capsule orally (roughly every 12 hours) for total of 2 doses, with the last dose being at least 4 hours prior to the scheduled colonoscopy.
If the colonoscopy is scheduled AT or AFTER 11a.m. the patient will receive in addition to PEG-ELS: Lubiprostone 24 mcg capsule orally 2 hours before each dose of the PEG-ELS

Colonoscopy Preparation

Standard of care for inpatient colonoscopy

PEG-ELS current standard of care

The dose of Lubiprostone will be 24 mcg capsule orally (roughly every 12 hours) for total of 2 doses, with the last dose being at least 4 hours prior to the scheduled colonoscopy if it is BEFORE 11 a.m., and Lubiprostone 24 mcg capsule orally 2 hours before each dose of the PEG-ELS if colonoscopy is scheduled AT or AFTER 11 a.m..

PEG-ELS current standard of care plus Lubiprostone 24 microgram Oral Cap (x2)

Ascension Providence Hopsital (Novi)

Ascension Providence Hospital, Southfield Campus

Ascension Macomb-Oakland Hospital

The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation

The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation.

The Boston Bowel Preparation Scale (BBPS) is a four-point scoring system (0-3) applied to each of the three broad regions of the colon: the right colon (including the cecum and ascending colon), the transverse colon (including the hepatic and splenic flexures), and the left colon (including the descending colon, sigmoid colon, and rectum). Scores can range from 0-9.

Adverse symptoms following colonoscopy can range from none (0) to severe (4)

any EHR documented adverse event during current hospitalization

Ascension South East Michigan

This group will receive a daily dose of 5000IU (125µg) vitamin D3 (which is half of the recommended safe tolerable upper intake level of vitamin D for healthy individuals) for eight weeks.

This group will receive 100% lactose placebo daily for eight weeks.

Cardiovascular Disease

Diabetes

Bone Disease

5000IU (125mcg) vitamin D3 tablet daily over 8 weeks (56 days).

Vitamin D3

100% Lactose tablet daily over 8 weeks (56 days).

Placebo

University of Chester

Effect of Vitamin D3 Supplementation on Cardiometabolic Risk

Effect of Vitamin D3 Supplementation on Cardiometabolic Risk Factors in a Cohort of Overweight and Obese Adults in the United Kingdom (UK)

I intend to report general participant characteristics, laboratory measurements and details of randomisation in my thesis after writing is complete by February 2017. IPD will possibly be published in nutrition and medical journals by September 2017.

ethylene/fetma

The Effect of Adding Lubiprostone to Standard Large-Volume PEG-ELS on The Quality of Inpatient Colonoscopy Preparation

Effect of Vitamin D3 Supplementation on Cardiometabolic Risk

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