20 preterm infants receive parenteral nutrition containing 20% MOFS lipid emulsion (Smoflipid ®)

20 preterm infants with sepsis receive the usual parenteral nutrition containing soybean oil based lipid emulsion (20% Intralipid ®) at daily increasing doses guided by serum triglycerides.

Sepsis Newborn

Smoflipid ®

Mansoura University Children Hospital

The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis

The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis: a Randomized Pilot Controlled Trial

changes in levels of sICAM-1 in septic preterm infants after receiving one of the two different lipid emulsions for seven days.

changes in leukocyte integrin ß2 level in septic preterm infants after receiving one of the two different lipid emulsions for seven days.

Effect of two different lipid emulsions on hospital stay duration in septic preterm infants

Effect of two different lipid emulsions on duration of antibiotics treatment in septic preterm infants

Effect of two different lipid emulsions on duration of mechanical ventilation in septic preterm infants

Effect of two different lipid emulsions on mortality rate in septic preterm infants

Yahya Wahba

Principal Investigator

Placebo ( 0.9% Normal saline) intravenously given as a 0.5 ml/kg loading dose over 15 minutes followed by a 0.1 ml/kg/hr continuous infusion throughout the surgery.

Tranexamic acid 100 mg/ml; 50 mg/kg loading dose = 0.5 ml/kg LD given over 15 minutes and 10 mg/kg/hr = 0.1 ml/kg/hr infusion for the duration of the surgery.

Placebo ( 0.9% Normal saline) intravenously given as a 0.5 ml/kg loading dose over 15 minutes followed by a 0.1 ml/kg/hr continuous infusion throughout the surgery.
Placebo: Following a standardized general anesthetic protocol, patients coming with idiopathic scoliosis will be randomized to:
Placebo ( 0.9% Normal saline) intravenously given as a 0.5 ml/kg loading dose over 15 minutes followed by a 0.1 ml/kg/hr continuous infusion throughout the surgery or
TXA as previously described.

Placebo

Tranexamic acid 100 mg/ml; 50 mg/kg loading dose = 0.5 ml/kg LD given over 15 minutes and 10 mg/kg/hr = 0.1 ml/kg/hr infusion for the duration of the surgery.
Tranexamic Acid: Following a standardized general anesthetic protocol, patients coming with idiopathic scoliosis will be randomized to either:
placebo i.e. saline 0.9% (intravenous injection)
intravenous TXA given as a loading dose over 15 minutes of 50 mg/kg bolus ( within an hour prior to surgical incision) and 10 mg/kg/hr infusion for the duration of the surgery.

Tranexamic Acid

Total

Sex: Female, Male

Race (NIH/OMB)

weight

The ASA PHYSICAL STATUS CLASSIFICATION SYSTEM scale is 1-6, ASA 1 being the lowest risk and ASA4 being the higher risk as follows ( ASA 5 AND 6 DO NOT APPLY TO THIS POPULATION):
ASA I A normal healthy patient ASA II A patient with mild systemic disease ASA III A patient with severe systemic disease ASA IV A patient with severe systemic disease that is a constant threat to life ASA V A moribund patient who is not expected to survive without the operation ASA VI A declared brain-dead patient whose organs are being removed for donor purposes

American Society of Anesthesiology Physical Status Classification

Perioperative blood loss (during operation and for entire hospital admission)

Perioperative Blood Loss

Overall Study

susan Goobie, MD, FRCPC

Adolescent Idiopathic Scoliosis

Following a standardized general anesthetic protocol, patients coming with idiopathic scoliosis will be randomized to either:
placebo i.e. saline 0.9% (intravenous injection)
intravenous TXA given as a loading dose over 15 minutes of 50 mg/kg bolus ( within an hour prior to surgical incision) and 10 mg/kg/hr infusion for the duration of the surgery.

Following a standardized general anesthetic protocol, patients coming with idiopathic scoliosis will be randomized to:
Placebo ( 0.9% Normal saline) intravenously given as a 0.5 ml/kg loading dose over 15 minutes followed by a 0.1 ml/kg/hr continuous infusion throughout the surgery or
TXA as previously described.

ethylene/seizures

The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis

Does Tranexamic Acid Decrease Blood Loss in Pediatric Idiopathic Scoliosis Surgery?

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