fissure in ano/arginine

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Treatment of chronic anal fissure by application of L-arginine gel: a phase II study in 15 patients.

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OBJECTIVE Local application of exogenous nitric oxide donors, such as isosorbide dinitrate and glyceryl trinitrate, promotes fissure healing by reducing anal resting pressure and improving anodermal blood flow. The major drawback of these nitric oxide donors is headache. The overall incidence of

Topical L-arginine gel lowers resting anal pressure: possible treatment for anal fissure.

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OBJECTIVE Exogenous nitric oxide donors, such as glyceryl trinitrate, have been used as treatment for anal fissures; however, headaches develop in 60 percent of patients. Nitric oxide produced from the cellular metabolism of L-arginine mediates relaxation of the internal anal sphincter. This study

L-arginine-induced relaxation of the internal anal sphincter is not mediated by nitric oxide.

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BACKGROUND Topical application of L-arginine, the precursor of nitric oxide, reduces resting anal pressure without significant side-effects and may therefore be of benefit in the treatment of anal fissure. This in vitro study investigated the effect of L-arginine on sheep and human isolated internal

The effect of oral administration of L-arginine on anal resting pressure and anodermal blood flow in healthy volunteers.

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BACKGROUND Topical application of L-arginine, the precursor of nitric oxide, reduces anal resting pressure without significant side effects and may therefore be of benefit in the treatment of anal fissure. This in vivo study investigated the effect of orally administered L-arginine on anal resting

Non surgical therapy for anal fissure.

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BACKGROUND Because of the disability associated with surgery for anal fissure and the risk of incontinence, medical alternatives for surgery have been sought. Most recently, pharmacologic methods that relax the anal smooth muscle, to accomplish reversibly what occurs in surgery, have been used to

Relaxation effects of adrenomedullin in carbachol-precontracted rabbit internal anal sphincter.

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BACKGROUND The internal anal sphincter is a specialized continuation of the circular smooth muscle layer of the rectum. It has been found that internal anal sphincter tonus is significantly increased in the majority of patients with anal fissure. Adrenomedullin has a relaxant effect on smooth muscle

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