ganglion cysts/hyoscine

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[The effect of ganglion blocking agents on bladder hypertension and its clinical significance; experimental studies with hyoscine-n-butylbromide (buscopan)].

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Action of surugatoxin on nicotinic receptors in the superior cervical ganglion of the rat.

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Surugatoxin (SGTX, 0.1-2 muM) reversibly depressed orthodromic transmission and antagonized the depolarizing action of carbachol on the isolated superior cervical ganglion of the rat. The apparent dissociation equilibrium constant against carbachol-induced depolarization (measured in the presence of

Dose-response relationships of intravenous hyoscine butylbromide and atropine sulphate on heart rate in healthy volunteers.

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Heart-rate responses to intravenous hyoscine butylbromide, atropine and physiological saline in cumulative dosage regimens have been recorded in six healthy subjects. Atropine sulphate induced bradycardia at low, and tachycardia at higher, dose levels whereas hyoscine butylbromide caused only

The effects of hyoscine and anticholinesterases on cholinergic transmission to the smooth muscle cells of the avian gizzard.

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1. Intracellular recordings were made from smooth muscle cells of the pigeon and chick gizzards. Hyoscine (10(-6) g/ml.) blocked, within 2 min, the excitatory junction potentials (E.J.P.s) evoked by transmural stimulation. As the amplitudes of E.J.P.s decreased, their durations also decreased.

Hyoscine butylbromide: a review of its use in the treatment of abdominal cramping and pain.

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Abdominal cramping and pain is a frequent problem in the adult population of Western countries, with an estimated prevalence of < or =30%. Hyoscine butylbromide (scopolamine butylbromide) [Buscopan/Buscapina] is an antispasmodic drug indicated for the treatment of abdominal pain associated with

Mechanical effects of right atrial pressure on heart rate in the conscious rabbit.

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We attempted to detect and quantify the mechanical effects of change in right atrial pressure on the chronotropic properties of the cardiac pacemaker, when blood volume was altered in an isohaemic fashion by +/- 27% in 8 conscious rabbits. Under control conditions there was a strong negative

Muscarinic synaptic potentials in guinea-pig myenteric plexus neurones.

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1. Intracellular recordings were made from neurones in the myenteric plexus of the guinea-pig ileum in vitro. 2. A single pulse stimulus to the presynaptic fibres entering a myenteric ganglion elicited a fast excitatory post-synaptic potential (e.p.s.p.) in type 1 (S) cells: in about one-quarter of

Muscarinic receptors in rat sympathetic ganglia.

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1 Potential changes in isolated superior cervical ganglia of the rat produced by muscarinic-receptor agonists were recorded by an extracellular ;air-gap' method.2 Muscarinic agonists produced a delayed low-amplitude ganglion depolarization, frequently preceded by a hyperpolarization. Potentials were

Post-stimulus potentiation of transmission in pelvic ganglia enhances sympathetic dilatation of guinea-pig uterine artery in vitro.

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Vasodilatation produced by stimulation of preganglionic neurones in lumbar and sacral pathways to pelvic ganglia was studied using an in vitro preparation of guinea-pig uterine artery and associated nerves in a partitioned bath allowing selective drug application to the ganglia or artery. Arterial

Nerve-mediated excitation and inhibition of the smooth muscle cells of the avian gizzard.

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1. The electrical events evoked in smooth muscle cells of the chick and pigeon gizzards by vagal, perivascular sympathetic and transmural stimulation were recorded with intracellular micro-electrodes.2. Single stimulating pulses applied to the extrinsic nerves, or to intrinsic fibres, produced

Analysis of mechanisms responsible for the bradycardic action of naloxone after haemorrhage in the conscious rabbit.

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We have analyzed the efferent mechanisms responsible for the bradycardia that occurs when naloxone (6 mg/kg) is given i.v. to conscious rabbits after acute blood loss of 17-20 ml/kg. Atenolol and hyoscine methyl bromide were given intrapericardially (i.p.c.), singly and in combination, to allow

Depolarizing actions of gamma-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro.

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1 Potential changes in rat superior cervical ganglia were recorded in vitro with surface electrodes.2 gamma-aminobutyric acid (GABA) produced a transient, low-amplitude ganglion depolarization at rest, and a transient hyperpolarization in ganglia depolarized by carbachol. Depolarization was not

Effect of cholinergic antagonists on sympathetic ganglionic transmission of vasomotor reflexes from the carotid baroreceptors and chemoreceptors of the dog.

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1. In anaesthetized dogs the reflex vascular resistance changes in a perfused hind limb were studied following carotid baroreceptor or chemoreceptor stimulation. 2. The observed rises in resistance were sympathetically mediated and thus provided a means of studying the action of the cholinergic

[Cholinergic contraction of the dog urinary bladder by electrical stimulation of the n. pelvicus and the ligamenta lateralia nerves and its affection by atropine and scopolaminebutylbromide (author's transl)].

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As is well known contraction of the urinary bladder induced by electrical stimulation of the N. pelvicus-hypogastric plexus in the dog can only be diminished by atropine but not completely abolished. The result of stimulation can, however, be quantitatively abolished by the quaternary ammonium base

The action of nerveside, a peptide extracted from brain, on myenteric ganglia in Auerbach's plexus.

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1. In the rabbit jejunum nerveside causes alternating contractions of the longitudinal and circular muscles, which are similar to the peristaltic reflex produced by distension of the gut. These effects are abolished by dibucaine (Nupercaine) and tetrodotoxin. The site of action is located in

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